Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Diagnoses Disease Clinical Trial

— TREMORHYTHM  

Official title:

Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05998486
• Other study ID #: ARM-Tremor
• Status: Recruiting
• Start date: April 3, 2023
• Est. completion date: December 31, 2023

Study information

• Verified date: August 2023
• Source: Henri Mondor University Hospital
• Contact: Emilie Hutin, PhD
• Phone: +33149812549
• Email: emilie.hutin[@]aphp.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Description:

This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: December 31, 2023
• Est. primary completion date: September 30, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories;
• diagnosis of Parkinson's disease or cerebellar tremor.

Exclusion Criteria:

• Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings;
• Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
• Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings;
• Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Related Conditions & MeSH terms

• Cerebellar Neoplasms
• Diagnoses Disease
• Parkinson
• Parkinson Disease
• Rest Tremor
• Tremor

Intervention

Diagnostic Test:
• EMG in wrist flexor-pronators and extensor-supinators
The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Locations

Country	Name	City	State
France	Laboratoire Analyse et Restauration du Mouvement	Créteil

Sponsors (1)

Lead Sponsor	Collaborator
Henri Mondor University Hospital

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	rhythmicity index	The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.	10 seconds