Wound Healing Clinical Trial
Official title:
Effect of Supplementation With b- Hydroxy Methyl Butyrate and Glutamine in Wound Healing Histology in Type 2 Diabetes and Controls Bloody Areas
A randomized controlled clinical trial in two groups of supplementation with HMB and glutamine. Each group consist in 25 patients with bloody areas, one group will receive and intervention with HMB and Glutamine and the other will receive a placebo with calcium caseinate.
A fundamental part of the integral management of wound healing in patients with bloody areas
is nutrition, since it involves biochemical events that depend on the substrates it provides.
Wound healing is a phase that demands higher needs of energy-protein than the requirement.
Problem statement: Poor nutrition decreases, through specific phases, normal processes that
allow the progression of wound healing. Nutrient deficiencies can have negative effects on
wound healing by prolonging the inflammatory phase, decreasing fibroblast proliferation, and
modifying collagen synthesis. Some amino acids are essential for the process, such as
Glutamine and Hydroxymethylbutyrate.
Objective: To evaluate the effect of Glutamine and Hydroxymethylbutyrate supplementation over
the cells involved in wound healing of bloody areas. Hypothesis: Glutamine and
Hydroxymethylbutyrate supplementation promotes a positive effect over the cells involved in
wound healing of bloody areas. Methodology: A randomized controlled clinical trial, in
patients with diagnosis of bloody areas. They will be divided into two groups, the first will
receive an intervention with Glutamine (14g) and Hydroxymethylbutyrate (3g) and a control
group will receive a placebo with calcium caseinate (17g)
A sample of the affected tissue will be taken before and after the supplementation where
histology will be analyzed.
Remains of tissue will be obteined during surgery wash for histology.
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