Clinical Trial Details
— Status: Active, not recruiting
Administrative data
| NCT number |
NCT06356480 |
| Other study ID # |
266 |
| Secondary ID |
|
| Status |
Active, not recruiting |
| Phase |
Phase 1/Phase 2
|
| First received |
|
| Last updated |
|
| Start date |
October 1, 2023 |
| Est. completion date |
April 2024 |
Study information
| Verified date |
April 2024 |
| Source |
Pak Emirates Military Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Chronic diabetic wounds are those wounds that are persistent and do not respond to any sort
of treatment. The concept of using topical antiseptics on open wounds is to prevent and treat
infections. They also help to shorten the time taken to heal the wounds. The use of topical
agents on wounds to prevent infection is a minimal ability to develop resistance to the
microorganisms. Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen with innate
resistance to many antibiotics. In places that are economically backward, these problems get
compounded by the inability of patients to afford newer expensive drugs. Topically applied
dilute acetic acid, which is cheap and easily available, has been found to be effective in
such chronic diabetic wounds
Description:
Chronic diabetic wounds are those wounds that are persistent and do not respond to any sort
of treatment. The concept of using topical antiseptics on open wounds is to prevent and treat
infections. They also help to shorten the time taken to heal the wounds. The use of topical
agents on wounds to prevent infection is a minimal ability to develop resistance to the
microorganisms. Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen with innate
resistance to many antibiotics. In places that are economically backward, these problems get
compounded by the inability of patients to afford newer expensive drugs. Topically applied
dilute acetic acid, which is cheap and easily available, has been found to be effective in
such chronic wounds. They pose a major challenge that is cumbersome in terms of wound healing
and also add to the cost in terms of quality of life to the patient and is a financial burden
for the hospitals. Three main factors have been found to be the causative factors for the
development of a chronic wound: firstly, bacterial colonisation or commonly called bioburden;
secondly, reperfusion injury; and thirdly, cellular and systemic factors. Most of the wounds
if not all of them are contaminated with pathogenic microorganisms, but this itself does not
affect the healing of wounds. When the contamination increases to a point of critical
colonisation or infection, then the infection or the bioburden in the wound becomes a major
contributing factor that impedes wound healing. Chronic wounds do not progress to the
proliferative phase of wound healing and undergo a detention in the inflammatory phase of
healing because of which there is a continuous influx of neutrophils into the wound area,
with the release of free radicals, cytolytic enzymes and inflammatory mediators that cause
damage to the invading pathogens as well as to the host tissue. Poor blood supply results in
hypoxic conditions in tissues, which can lead to cell death and tissue necrosis. This
provides good growing conditions for pathogenic microorganisms leading to the establishment
and colonisation of bacteria in the host tissue.
