Healing Wound Clinical Trial
Official title:
Nutritional Regulation of Leukocyte Function
The objective of the current study is to determine the dose at which Fermented Papaya Preparation ( FPP) is able to improve inducible respiratory burst outcomes in peripheral blood mononuclear cells (PBMC) and neutrophils of participants. Our investigators have reported that supplementation with standardized fermented papaya preparation (FPP) in mice improves dermal wound healing outcomes. Therefore, based on these observations, the investigators propose to study the dose at which FPP supplementation induces respiratory burst in blood-derived myeloid cells in healthy subjects.
Fermented Papaya Preparation (FPP) is a dietary supplement that is available as over-the-counter in the US. FPP possesses antioxidant properties, which provide benefit against age-related complications[]. Chronic wounds in patients with diabetes represent a major public health problem. Previous studies from the investigators have demonstrated that wound-site macrophages from patients with diabetes are compromised in their ability to support wound healing. Several independent observations convergently point toward the hypothesis that treatment with papaya preparations may facilitate wound healing responses. Our laboratory reported the first evidence demonstrating that FPP may improve diabetic wound outcomes by specifically influencing the response of wound-site macrophages and the subsequent angiogenic response. FPP has a long track record of safe human consumption. The objective of the current study is to determine the dose at which FPP is able to improve inducible respiratory burst outcomes in peripheral blood mononuclear cells (PBMC) and neutrophils of participants. Our investigators have reported that supplementation with standardized fermented papaya preparation (FPP) in mice improves dermal wound healing outcomes. Therefore, based on these observations, the investigators propose to study the dose at which FPP supplementation induces respiratory burst in blood-derived myeloid cells in healthy subjects. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT06191510 -
Xenogenic Bone Intentionally Left Exposed
|
||
Active, not recruiting |
NCT05592158 -
Evaluation of the Effectiveness of an Amnion-chorion Membrane for Alveolar Ridge Preservation
|
N/A | |
Not yet recruiting |
NCT06276335 -
Influence of Timing of Implant Placement on Early Healing Molecular Events
|
N/A | |
Completed |
NCT05386667 -
Evaluation of the Effects of Medicaments Used After Free Gingival Graft on Postoperative Complications.
|
||
Completed |
NCT05297071 -
Longitudinal Monitoring of Microsurgical Socket Augmentation Healing With Ultrasonography
|
N/A | |
Not yet recruiting |
NCT04269694 -
Adjunctive Use of an Antibacterial Honey Dressing for Palatal Wound Healing After Harvesting a Free Gingival Graft
|
Phase 4 | |
Not yet recruiting |
NCT06017193 -
Ultrasound for Socket Healing Evaluation
|
||
Recruiting |
NCT05591651 -
Hyaluronic Acid for the Treatment of Damaged Nipples in Breastfeeding Women
|
Phase 4 | |
Enrolling by invitation |
NCT03050671 -
Effects of External Leg Compression Devices on Healing and Blood Clotting
|
N/A | |
Active, not recruiting |
NCT05753787 -
Eye Surface Properties After Using Dexamethasone Drops With and Without Preservatives in Patients After Cataract Surgery
|
N/A | |
Completed |
NCT05025306 -
Healing Effect of Ziziphus Honey on Extracted Tooth Socket in Humans by Evaluating the Levels of BMP-2 and OPN
|
Phase 3 | |
Recruiting |
NCT06173908 -
Autologous Epidermal Cell Treat for Nonhealing Postoperative Wound
|
N/A | |
Active, not recruiting |
NCT03631693 -
Imaging Analysis Following Periodontal Surgery
|
N/A | |
Completed |
NCT03699852 -
Effect of Photobiomodulation in a Partial Thickness Autogenous Skin Graft Donor Area
|
N/A | |
Not yet recruiting |
NCT04276168 -
Impact of Iron Stores on Wound Healing in Plastic Surgery
|
||
Completed |
NCT04467736 -
Wound Healing With Hyaluronic Acid After Alveolar Ridge Preservation
|
N/A | |
Completed |
NCT05339828 -
Unroofing Curettage for Pilonidal Disease
|