Diabetic Retinopathy Clinical Trial
Official title:
Immunopathology and Molecular Pathology of Ocular Diseases in Humans
The purpose of this project is to diagnose and evaluate ocular and related tissues with
various diseases such as conjunctival, corneal, uveal, vitreoretinal and optic nerve
disorders, ocular degenerative, metabolic or genetic diseases and tumors. These will be
studied using light microscopy, electron microscopy, confocal microscopy,
immunohistochemistry, molecular pathological including polymerase chain reaction and in situ
hybridization, as well as measuring the functions of cellular organelles, e.g., mitochondrial
function. Lymphocytes in the peripheral blood as well as other involved biopsied tissues and
ocular tissue will be compared and categorized by disease. Cytokines, chemokines or growth
factors and/or other released molecules in the blood and ocular fluids will be also analyzed.
Elucidating the relationship between the infiltrating cells, ocular resident cells, and their
products in various diseases will help us to make diagnoses and increase our understanding of
human ocular disorders.
Patients who require eye surgery to treat an eye disease or other disease in which the eye is
involved may participate in this study. Samples of eye tissue and fluid that are normally
removed and discarded during eye surgery will instead be given to researchers for study. The
tissues will be examined under microscope and studied using sophisticated chemical and
biological tests. Immune cells from blood samples may also be examined. These studies will
help better understand and diagnose the various eye diseases and to develop more attractive
therapies.
The purpose of this project is to diagnose and evaluate ocular and related tissues with various diseases such as conjunctival, corneal, uveal, vitreoretinal, scleral, optic nerve, and orbital disorders, ocular degenerative, inflammatory, metabolic or genetic diseases, and tumors. These will be studied using light microscopy, electron microscopy, confocal microscopy, immunohistochemistry, molecular pathology including microdissection and polymerase chain reaction and in situ hybridization, ELISA, as well as measuring the functions of cellular organelles, e.g., mitochondrial function. Lymphocytes in the peripheral blood, serum, as well as other involved biopsied tissues and ocular tissue will be compared and categorized by disease and normal. Cytokines, chemokines, growth factors, antibodies, and/or other released molecules in the blood, CSF, and ocular fluids will be also analyzed. We will compare the tissue morphology as well as immunological and biochemical indexes, e.g., cytokine/chemokine levels, growth factors, and antibodies between the diseases and normals. Elucidating the relationship between the infiltrating cells, ocular resident cells, and their products in various diseases will help us to make diagnoses, increase our understanding of human ocular disorders, and assist therapy. ;
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