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Clinical Trial Summary

Diabetic neuropathy (DN) is the most common complication of diabetes, affecting almost 50% of people with diabetes over the course of their lives. Symptoms vary from numbness to burning, aching and hypersensitivity in the lower limbs, indicative of sensory nerve loss. Motor neurons can also be affected, leading to muscle weakness and mobility issues, thus preventing patients from engaging in daily routines. Further sequelae include foot ulceration and Charcot neuroarthropathy, which are risk factors for lower limb amputation and mortality. In the United Kingdom, the annual costs of DN alone exceed £300 million, with further complications expected to cost an additional £1 billion. Currently, management strategies for DN focus on prevention and pain management. Neuromuscular electrical stimulation (NMES) is a novel nonpharmacological intervention for people with DN. NMES is the application of electrical impulses which are of sufficiency intensity to improve artificial contraction of the muscle tissue and may help with DN by improving nerve conductivity through direct stimulation of the nerves.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT03767478
Study type Interventional
Source Imperial College London
Contact Tristan R A Lane, MBBS BSc FRCS PhD
Phone 02033117317
Email tristan.lane@imperial.ac.uk
Status Not yet recruiting
Phase N/A
Start date August 1, 2023
Completion date December 31, 2024

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