Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

Diabetic Kidney Injury Clinical Trial

Official title:

Predictive Value of Serum Uric Acid to High Density Lipoprotein Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06349850
• Other study ID #: Soh-Med-24-03-06MS
• Status: Not yet recruiting
• Start date: June 2024
• Est. completion date: September 2024

Study information

• Verified date: May 2024
• Source: Sohag University
• Contact: Eldeeb E. Mohamed, Resident
• Phone: 01092700322
• Email: deebbayern13[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes

Description:

Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: September 2024
• Est. primary completion date: September 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• Type 2 diabetic patients
• willing and agreed to be included in the study

Exclusion Criteria:

• Type 1 DM patients
• patients with active urinary sediment
• patients with glomerulonephritis
• patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease
• patients with evidence of alternative kidney disease
• patients with history of kidney transplantation
• patients with end stage renal disease
• patients with family history of non diabetic forms of kidney disease
• patients with active malignancy
• patients with established hemolytic disease
• CKD patients requiring dialysis
• patients taking drugs that interfere with serum uric acid level
• patients taking drugs that alter serum lipids level
• pregnancy
• Refused to consent to this study

Related Conditions & MeSH terms

• Wounds and Injuries

Intervention

Diagnostic Test:
• serum uric acid level to plasma HDL-c level ratio (UHR)
high UHR is considered to be a risk factor for development of DKI in type 2 DM

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

References & Publications (4)

Evans K, Pyart R, Steenkamp R, Whitlock T, Stannard C, Gair R, McCann J, Slevin J, Medcalf J, Caskey F. UK Renal Registry 20th Annual Report: Introduction. Nephron. 2018;139 Suppl 1:1-12. doi: 10.1159/000490958. Epub 2018 Jul 10. No abstract available. — View Citation

Koye DN, Shaw JE, Reid CM, Atkins RC, Reutens AT, Magliano DJ. Incidence of chronic kidney disease among people with diabetes: a systematic review of observational studies. Diabet Med. 2017 Jul;34(7):887-901. doi: 10.1111/dme.13324. Epub 2017 Mar 9. — View Citation

National Kidney Foundation. KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update. Am J Kidney Dis. 2012 Nov;60(5):850-86. doi: 10.1053/j.ajkd.2012.07.005. Erratum In: Am J Kidney Dis. 2013 Jun;61(6):1049. — View Citation

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R; IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019 Nov;157:107843. doi: 10.1016/j.diabres.2019.107843. Epub 2019 Sep 10. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Uric acid to HDL-c ratio (UHR)	asociation of high UHR with development of DKI in type 2 DM	6 months