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NCT06355960 Clinical Trial

Effect of Dexmedetomidine on Oxygenation and Lung Mechanics

Dexmedetomidine Clinical Trial

Official title:
Effect of Different Does of Dexmedetomidine on Oxygenation and Lung Mechanics

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06355960
Other study ID # 2024-853
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date April 1, 2024
Est. completion date May 1, 2025

Study information
Verified date April 2024
Source Cairo University
Contact Amr S Wahdan, MD
Phone 00201001422499
Email amrwahdan@kasralainy.edu.eg
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 176
Est. completion date May 1, 2025
Est. primary completion date April 1, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Morbidly obese patients with restrictive lung disease ASA I AND II laparoscopic sleeve gastrectomy Exclusion Criteria: history of heart failure history of cardiac arrhythmias severe liver or kidney impairment. Patients with forced expiratory volume in 1 sec (FEV1)/ FVC < 70%

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• GROUP Dexmedetomidine
Dexmedetomidine (Precedex) loadings of 1 µg/kg , then continuously at a rate of 0.2 µg/(kg/h) till the end of the operation .
• GROUP B
Dexmedetomidine (Precedex) loadings of 0.5 µg/kg , then continuously at a rate of 0.2 µg/(kg/h) till the end of the operation .
• GROUP C
Dexmedetomidine (Precedex) loadings of 0.25 µg/kg, then continuously at a rate of 0.2 µg/(kg/h) till the end of the operation .

Locations
Country Name City State
Egypt Cairo university Cairo

Sponsors (1)
Lead Sponsor Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Oxygenation by the end study PaO2/Fraction of inspired oxygen UP TO 6 HOURE
Secondary Intraoperative dynamic lung compliance tidal volume/ (peak airway pressure -PEEP) up to 6 hours
Secondary Intraoperative static lung compliance Tidal volume/ (plateau pressure - PEEP) UP TO 6 HOURE
Secondary Physiological dead space 1.14 (PaCO2-EtCO2)/ PaCO2-0.005 UP TO 6HOURE
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