Dexmedetomidine Clinical Trial
Official title:
Comparative Study Between the Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic Cholecystectomy
This study will be carried out to compare the efficacy of dexmedetomidine, propofol or lidocaine infusions in attenuation of hemodynamic responses to pneumoperitoneum during adult laparoscopic cholecystectomy using electrical cardiometry.
Status | Recruiting |
Enrollment | 80 |
Est. completion date | October 30, 2023 |
Est. primary completion date | October 30, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 60 Years |
Eligibility | Inclusion Criteria: - American Society of Anesthesiologists I patients. - Patients between the ages of = 20 and = 60 years of both sexes. Exclusion Criteria: - Hypersensitivity to dexmedetomidine, propofol or lidocaine. - Diabetic patients (Hemoglobin A1C = 7). - Hypertensive patients (Blood presssure = 140/90 mmHg) or patients on medications that affect hemodynamics as clonidine, methyldopa, ß blockers and calcium channel blockers. - Impaired liver function (serum albumin = 3.5 g/dl, International normalized ratio= 1.3, total bilirubin >1mg/dl). - Impaired renal function (serum creatinine >1.2 mg/dl, blood urea >20mg/dl). - Morbidly obese patients with body mass index = 40. - Patients with acute cholecystitis or active infection. - Patients taking medications that may impair cognition. - History of seizures. |
Country | Name | City | State |
---|---|---|---|
Egypt | Menoufia University | Shibin Al Kawm | Menoufia |
Lead Sponsor | Collaborator |
---|---|
Menoufia University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Noninvasive mean blood pressure | mean blood pressure will be noted by a standard automated multi channel monitor will be connected to each patient | Intraoperatively | |
Secondary | Intraoperative rescue drugs | Patients that will need rescue drugs (fentanyl) will be recorded with the total dose used. | Intraoperatively | |
Secondary | Post extubation sedation | Post extubation sedation assessment will be done in each group using Ramsey's sedation score.
Anxious, agitated or restless = (1) Cooperative, oriented and tranquil = (2) Responsive to command only = (3) Brisk response to light glabellar tap or loud auditory stimulus = (4) Sluggish response to light glabellar tap or loud auditory stimulus = (5) No response = (6) |
24 hour postoperatively |
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