Effect of Lidocaine Plus Dexmedetomidine Infusion on PONV

Status Completed

Clinical Trial Summary

BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV). The investigators investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the incidence of PONV after laparoscopic hysterectomy.

METHODS: One hundred and twenty women with elective laparoscopic hysterectomy were randomly divided into two groups: patients in the lidocaine combined with dexmedetomidine group (LD group, n=60) received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine (0.5 μg/kg loading, 0.4 μg/kg/h infusion) respectively. Patients in the control group (CON group, n=60) received the equal volume of saline. Primary outcome was the incidence of the first 48 h nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation score, and bradycardia during post-anaesthesia care unit (PACU) stay.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Dexmedetomidine
Lidocaine
Nausea
Nausea and Vomiting, Postoperative
Postoperative Nausea and Vomiting
Vomiting

Clinical Trial Details

NCT number	NCT03788018
Study type	Interventional
Source	Anqing Municipal Hospital
Contact
Status	Completed
Phase	N/A
Start date	January 1, 2018
Completion date	December 1, 2018

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