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Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia

Dexmedetomidine Clinical Trial

Official title:
The Effects of Dexmedetomidine on the Neurotoxicity From General Anesthesia Assessed by Plasma Glial Fibrillary Acidic Protein

Clinical Trial Summary

Neuroapoptosis is induced by the administration of anesthetic agents to the young brain. Recent studies showed that the a2-adrenoceptor agonist, dexmedetomidine plays a trophic role during development and is neuroprotective in several settings of neuronal injury in animals. We hypothesized that neuroprotective effect of dexmedetomidine would be associated with evidence of brain injury detected by elevation of plasma concentration of glial fibrillary acid protein in children undergoing general anesthesia.

Clinical Trial Description

GFAP measure ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03234660
Study type Interventional
Source Seoul National University Hospital
Contact
Status Completed
Phase N/A
Start date September 1, 2017
Completion date October 5, 2019
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