Parkinson's Disease Clinical Trial
Official title:
The Use of Toxin Botulinum A Toxin in Patients With Parkinson's Disease and Multiple System Disease, Affected by Refractory Detrusor Overactivity.
The researchers investigated the effectiveness and safety of BoNT/A injected into the detrusor muscle in patients with PD and MSA all of whom had detrusor muscle overactivity unresponsive to conventional medical therapy.
Patients included will have overactive bladder symptoms refractory to medical therapy. Other
causes of overactive bladder symptoms including urogenital prolapse and recurrent urinary
tract infections were excluded. None of the patients will be under anticoagulant therapy or
drugs interfering with neuromuscular transmission. The study was approved by the local
ethical committee and patients gave their informed consent. Patients will be informed about
the possible need for intermittent catheterization after BoNT/A treatment.
As outcome measures we assessed clinical and urodynamic variables.
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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