Desmoid Tumor Clinical Trial
Official title:
A Randomized, Double-blind, Phase Ⅲ Study of Liposomal Doxorubicin in Desmoid Tumor
The aim of this study was to evaluate the efficacy and safety of liposomal doxorubicin in the treatment of desmoid tumors. Unless the subject withdraws from the trial voluntarily, or the researcher considers that the subject is not suitable for further trial, each subject will be treated until the disease progresses or the toxic and side effects caused by the drug are intolerable, and then enter the survival follow-up period
A randomized, double-blind, placebo-controlled study designed to compare (PFS) differences in progression-free survival in patients treated with liposome doxorubicin or placebo. PFS is defined as the time from randomization to the first occurrence of disease progression or death caused by any cause. If the disease is stable, PFS will be calculated at the time of the last follow-up in the study. Patients who have reached the maximum follow-up period and have no progress will be reviewed on the date of the last disease assessment. The crossover data of the patients were analyzed and summarized separately from the data of the main treatment process.In this study, 72 patients were expected to be enrolled in the group for 12 months and followed up for 24 months.Patients will be randomized to receive liposome adriamycin (50mg/m2) or intravenous placebo for a treatment cycle of once every 28 days.Duration of medication: a total of 6 cycles, or to the progression of the disease, tolerable toxicity, whichever occurs first.As the disease progresses, patients treated with placebo will be allowed to enter the unblinded liposome adriamycin group. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00287846 -
Imatinib Mesylate in Treating Patients With Recurrent or Refractory Fibromatosis
|
Phase 1/Phase 2 | |
Recruiting |
NCT06258421 -
Burden of Disease and Living Situation in Desmoid Patients
|
||
Completed |
NCT00030680 -
Radiation Therapy in Treating Patients With Aggressive Fibromatoses
|
Phase 2 | |
Recruiting |
NCT06081400 -
Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting
|
N/A | |
Active, not recruiting |
NCT04871282 -
A Study of AL102 in Patients With Progressing Desmoid Tumors
|
Phase 2/Phase 3 | |
Recruiting |
NCT01567046 -
Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas
|
N/A | |
Completed |
NCT01137916 -
Study to Evaluate Imatinib in Desmoid Tumors
|
Phase 2 | |
Completed |
NCT00002595 -
Toremifene in Treating Patients With Desmoid Tumors
|
Phase 2 | |
Completed |
NCT03459469 -
Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059
|
Phase 1 | |
Completed |
NCT06195085 -
CT-guided Radioactive Iodine-125 Seed Implantation for Recurrent Desmoid Tumors
|
||
Completed |
NCT01286662 -
A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome
|
N/A | |
Completed |
NCT01265030 -
A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis
|
Phase 1/Phase 2 | |
Completed |
NCT00068419 -
Sulindac and Tamoxifen in Treating Patients With Desmoid Tumor
|
Phase 2 | |
Completed |
NCT04289077 -
Quality of Life of Patients With Desmoid-type Fibromatosis
|
||
Completed |
NCT03190174 -
Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers
|
Phase 1/Phase 2 | |
Completed |
NCT00003019 -
Vinblastine and Methotrexate in Treating Children With Desmoid Tumors
|
Phase 2 | |
Recruiting |
NCT05949099 -
Study of Cryoablation and Nirogacestat for Desmoid Tumor
|
Phase 2 | |
Active, not recruiting |
NCT02076906 -
MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors
|
Phase 1 | |
Completed |
NCT00474994 -
Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas
|
Phase 2 | |
Active, not recruiting |
NCT03785964 -
Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)
|
Phase 3 |