| Eligibility |
Inclusion Criteria:
1. Male and female patients 18 through 65 years of age.
2. Women of childbearing potential (WOCBP) must not be actively seeking pregnancy, and
must use an effective form of birth control (confirmed by the Investigator). Effective
forms of birth control include: true sexual abstinence, a vasectomized sexual partner,
Implanon, female sterilization by tubal occlusion, any effective intrauterine device
(IUD)/ levonorgestrel Intrauterine system (IUS), Depo-Provera™ injections, oral
contraceptive, and Evra Patch™ or Nuvaring™. WOCBP must agree to use effective method
of birth control, as defined above, from enrolment, throughout the study duration and
within 16 weeks after last dose of IP. They must demonstrate a negative serum
pregnancy test at screening and demonstrate a negative urine pregnancy test
immediately before each dose of study drug or placebo. Women not of childbearing
potential are defined as women who are either permanently sterilized (hysterectomy,
bilateral oophorectomy, or bilateral salpingectomy), or who are postmenopausal. Women
will be considered postmenopausal if they have been amenorrheic for 12 months prior to
the planned date of randomization without an alternative medical cause. The following
age-specific requirements apply:
- Women <50 years old would be considered postmenopausal if they have been
amenorrheic for 12 months or more following cessation of exogenous hormonal
treatment and follicle stimulating hormone (FSH) levels in the postmenopausal
range.
- Women =50 years old would be considered postmenopausal if they have been
amenorrheic for 12 months or more following cessation of all exogenous hormonal
treatment.
3. All male patients who are sexually active must agree to use an acceptable method of
contraception (condom with or without spermicide, vasectomy) from the first dose of
investigational product (IP) until 16 weeks after their last dose.
4. General good health
5. Moderate to severe atopic dermatitis
6. Able to understand and give written informed consent and has signed a written informed
consent form approved by the investigator's Research Ethics Board (REB)
The following inclusion criteria must be met for entry into the dosing phase of the study:
1. Positive skin-prick test to common aeroallergens (including cat, dust mite, grass,
pollen)
2. Positive late cutaneous response to intradermal allergen challenge
Exclusion Criteria:
1. History of anaphylaxis to any biologic therapy or vaccine
2. History of clinically significant hypotensive episodes or symptoms of fainting,
dizziness, or light headedness, as judged by the investigator
3. Any history or symptoms of cardiovascular disease, particularly coronary artery
disease, arrhythmias, hypertension, or congestive heart failure
4. Any history or symptoms of significant neurologic disease, including transient
ischemic attack (TIA), stroke, seizure disorder, or behavioral disturbances
5. Any history or symptoms of clinically significant autoimmune disease
6. Any history of clinically significant haematologic abnormality, including coagulopathy
or any history of chronic treatment with anticoagulants (e.g. warfarin, etc) or
antiplatelet agent (e.g, aspirin, etc)
7. Clinically significant abnormalities in laboratory test results at enrolment and
during the screening period (including complete blood count, coagulation, chemistry
panel and urinalysis) unless judged not significant by the investigator.
8. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level =2.5 times
the upper limit of normal (ULN) confirmed during screening period
9. Being pregnant or lactating or have positive serum pregnancy test at enrolment or
positive urine pregnancy test during the study
10. Concomitant disease or condition which could interfere with the conduct of the study,
or for which the treatment might interfere with the conduct of the study, or which
would, in the opinion of the investigator, pose an unacceptable risk to the patient in
this study, including, but not limited to, cancer, alcoholism, drug dependency or
abuse, or psychiatric disease
11. Severe concomitant illness(es) that, in the investigator's judgment, would adversely
affect the patient's participation in the study
12. Presence of skin comorbidities that may interfere with study assessments
13. History of cancer: Patients who have had basal cell carcinoma, localized squamous cell
carcinoma of the skin, or in situ carcinoma of the cervix are eligible provided that
the subject is in remission and curative therapy was completed at least 12 months
prior to the date informed consent. Patients who have had other malignancies are
eligible provided that the subject is in remission and curative therapy was completed
at least 5 years prior to the date of informed consent.
14. Patient who has a scheduled in-patient surgery or hospitalization during the study.
15. History of Guillain-Barré syndrome
16. A helminth parasitic infection diagnosed within 24 weeks prior to the date informed
consent is obtained that has not been treated with, or has failed to respond to
standard of care therapy
17. Positive hepatitis B surface antigen, or hepatitis C virus antibody serology, or a
positive medical history for hepatitis B or C. Patients with a history of hepatitis B
vaccination without history of hepatitis B are allowed to enrol
18. A history of known immunodeficiency disorder including a positive human
immunodeficiency virus (HIV) test
19. Receipt of immunoglobulin or blood products within 30 days prior to the date informed
consent is obtained
20. Receipt of any marketed (eg omalizumab) or investigational biologic within 4 months or
5 half-lives prior to randomization is obtained, whichever is longer
21. Treatment with an investigational drug within 8 weeks or within 5 half-lives (if
known), whichever is longer, before the baseline visit
22. Any allergen immunotherapy within 4 months prior to or throughout the study.
23. Having used any of the following treatments within 4 weeks before the Day -2 baseline
visit, or any condition that, in the opinion of the investigator, is likely to require
such treatment(s) during study:
1. Immunosuppressive/immunomodulating drugs (eg, systemic corticosteroids,
cyclosporine, mycophenolate-mofetil, interferon gamma (IFN-?), Janus kinase
inhibitors, azathioprine, methotrexate, etc.)
2. Phototherapy for AD
24. Any cell-depleting agents including but not limited to rituximab: within 6 months
before the baseline visit, or until lymphocyte count returns to normal, whichever is
longer
25. Initiation of treatment of AD with prescription moisturizers or moisturizers
containing additives such as ceramide, hyaluronic acid, urea, or filaggrin degradation
products during the screening period (patients may continue using stable doses of such
moisturizers if initiated before the screening visit)
26. Regular use (more than 2 visits per week) of a tanning booth/parlor within 4 weeks of
the baseline visit
27. Active chronic or acute infection requiring treatment with systemic antibiotics,
antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks before the
baseline visit, or superficial skin infections within 1 week before the baseline
visit. Note: patients may be re-screened after infection resolves
28. Known or suspected history of immunosuppression, including history of invasive
opportunistic infections (eg, histoplasmosis, listeriosis, coccidioidomycosis,
pneumocystosis, aspergillosis) despite infection resolution: or unusually frequent,
recurrent, or prolonged infections, per investigator judgment
29. Planned or anticipated major surgical procedure during the patient's participation in
this study
30. Receipt of live attenuated vaccines 30 days prior to the date of randomization.
Receipt of inactive/killed vaccinations (eg, inactive influenza) are allowed provided
they are not administered within 1 week before/after any IP administration.
31. Patient is a member of the investigational team or his/her immediate family
32. Pregnant woman
33. Previously received benralizumab (MEDI-563)
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