Traumatic Brain Injury Clinical Trial
Official title:
A Pilot Safety and Feasibility Study of High Dose Left Prefrontal Transcranial Magnetic Stimulation (TMS) to Rapidly Stabilize Suicidal Patients With PTSD
The purpose of this study is to determine whether transcranial magnetic stimulation (TMS) is effective in the treatment of suicidal thinking in individuals with a depressive episode and either posttraumatic stress disorder (PTSD), history of mild traumatic brain injury (TBI), or both conditions.
Evidence suggests that depression in general, and suicidal ideation in particular, results
from a dysfunctional regulatory pathway involving prefrontal cortical governance over limbic
activity. Repeated daily non-invasive stimulation of the prefrontal cortex with TMS would
theoretically strengthen and reset this cortical control pathway and reduce suicidal ideation
and restore healthy circuit behavior.
The aim of the current study is to assess the efficacy of TMS therapy in the treatment of
suicidal ideation in patients with depressive episode(s) and either PTSD or mild TBI or both.
It is hypothesized that participants who receive repetitive TMS (Group 1) relative to sham
treatment (Group 2) three times daily over three days will evidence more improvement in
suicidal ideation from baseline to the end of day 3. Participants will be followed for six
months following treatment to assess safety and long-term efficacy of TMS.
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