A Comparison Study of Hypersensitivity Treatment

Status Completed

Clinical Trial Summary

The goal of this clinical trial is to evaluate the effect of 3M™ Clinpro™ Fluoride Aqueous Solution (experimental) on Dentin Hypersensitivity (DHS) in comparison to 3M™ Vanish™ (commercialized, control] in patients who have DHS. Participants will be asked to complete the following activities: Undergo a pre-treatment washout period for 3- to 6-weeks (± 4 days) post-enrollment. During this time, the Subject is to only use the provided oral hygiene products. Hypersensitivity will be assessed prior to (baseline) and immediately after sample application. Subject will be asked to come to the facility for hypersensitivity assessments at 24 hours, 7 days, and 30 days after the treatment visit. Researchers will compare 3M™ Clinpro™ Fluoride Aqueous Solution to 3M™ Vanish™ to evaluate if the effect of Clinpro™ on DHS treatment is non-inferior to Vanish™.

Clinical Trial Description

After Informed Consent has been obtained, the subjects will be given study supplied oral hygiene products (e.g., toothbrush and toothpaste) to be used immediately after the consent visit and throughout the entire duration of the study. Subjects will have a minimum wash-out period of 3 weeks followed by 1 treatment visit. At the treatment visit, a pain assessment will be performed (ie, a baseline pain score) in response to both an air-blast stimulus and tactile stimulus. After each stimulus, the Subject should score their pain using a Visual Analog Scale (VAS). After recording baseline pain scores, Clinpro™ (Treatment arm) or Vanish™ (Control arm) will be applied according to the manufacturer's IFU. Pain in response to air blast and probe test will be assessed using VAS immediately after application of fluoride treatment (within 15 minutes). Pain response will be assessed again at 24 h, 7 d, 21 d and 30 d post-application of the treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05768373
Study type	Interventional
Source	3M
Contact
Status	Completed
Phase	N/A
Start date	April 4, 2023
Completion date	July 14, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04249336` - Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH	Phase 3
Completed	`NCT00763269` - The Efficacy of a Toothpaste to Reduce Sensitivity	Phase 3
Recruiting	`NCT06154941` - Clinical Evaluation of Giomer Based Varnish Versus CPP-ACP Varnish in the Management of Dentin Hypersensitivity: a Randomized Clinical Trial	N/A
Completed	`NCT05501691` - Effect of Diode Laser on Sensitive NCCLs Prior to Composite Restoration	N/A
Not yet recruiting	`NCT04484844` - Clinical Evaluation of Efficacy of Shield Force Plus Varnish VS Sodium Fluoride on Dentin Hypersensitivity	Phase 2/Phase 3
Completed	`NCT02936830` - Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity	Phase 4
Completed	`NCT02931734` - Assessment of Different Protocols for Cervical Dentin Hypersensitivity Treatment	N/A
Completed	`NCT04512625` - Desensitizers in Reducing Post Tooth Preparation Sensitivity for a Fixed Dental Prosthesis	N/A
Completed	`NCT05623761` - Toothpastes With Thermal Water for Oral Health	Phase 4
Not yet recruiting	`NCT04731766` - Effect of Using Different Varnishes on Dentin Hypersensitivity; Na Fluoride and Nano-silver Fluoride	N/A
Recruiting	`NCT05927831` - Grape Seed Extract VS Low Level Laser Therapy for Dentin Hypersensitivity	N/A
Completed	`NCT03943095` - Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity	Phase 2
Not yet recruiting	`NCT06276777` - The Effect of Using Desensitizers Containing S-PRG In Treatment Of Dentin Hypersensitivity Over 6 Months: A Randomized Clinical Trial	N/A
Completed	`NCT04225247` - Efficacy of Seventh Generation Bonding Agents as Short-Term Desensitizers Among Patients With Hypersensitivity	Phase 3
Completed	`NCT04887181` - The Effects of Different Dentin Hypersensitivity Treatment Methods on Quality of Life	N/A
Not yet recruiting	`NCT03061383` - Reduction of Dentine Hypersensitivity Using 8% Arginine Based Toothpaste and 8% Strontium Acetate Based Toothpaste (DH)	N/A
Recruiting	`NCT03076944` - Evaluation of Desensitization Protocols in Reduction of Dentin Hypersensitivity	N/A
Recruiting	`NCT03083496` - Clinical Evaluation of Different Potassium Oxalate Concentrations in Dentin Hypersensitivity Treatment	N/A
Not yet recruiting	`NCT06264453` - A Study to Evaluate the Efficacy and Safety of KH001 in Patients With Dentin Hypersensitivity	Phase 2
Completed	`NCT03965039` - A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity	N/A