Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Dental Plaque Clinical Trial

Official title:

Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05258955
• Other study ID #: 1030419MAOM
• Status: Completed
• Phase: Phase 1
• Start date: June 3, 2020
• Est. completion date: January 21, 2021

Study information

• Verified date: February 2022
• Source: Liaquat National Hospital & Medical College
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The rationale of our study is to compare the efficacy of natural honey base preparation with other commercially available mouthwashes i.e chlorhexidine base in prevention of dental plaque formation as honey is readily available and cost effective and organic in nature. This study will help to provide the data of our community and positive result may provide a new method of oral hygiene maintenance with fewer side effects. We will be able to deliver the best anti-plaque agent.

Description:

In this study, participants will assigned into 2 group those who will fulfilled the inclusion and exclusion criteria. After the informed consent, they were divided into 2 group. Group A will received Chlorhexidine mouthwash and Group B will provided with honey based mouthwash. The participant will blinded as solution will be provided in dark color bottle to mask the study. After which the baseline plaque index will be taken followed by recording plaque index on 7th, 14th, and 21st day. The statistical analysis will be done to compare the mean difference between these 2 groups

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: January 21, 2021
• Est. primary completion date: December 30, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 25 Years

Eligibility

Inclusion Criteria:

1. Individual aged between 18-25

2. Retained 28 number of teeth excluding wisdom teeth

Exclusion Criteria:

1. Individual with medical illness affecting oral cavity like diabetes, sjögren syndrome, crohn disease etc

2. Multiple extraction , overhang restoration, wearing any appliance

3. Periodontal problem with pocket depth more than 3mm

4. Current or recent history of antibiotic consumption

5. Noncompliance that is unable to maintain their hygiene.

6. Pan, Betel quid and any other oral habit will not be included in study

Related Conditions & MeSH terms

• Dental Plaque

Intervention

Other:
• Natural honey
Natural Sidr honey based mouthwash used as intervention group B (Arm Group B) for the reduction of plaque index

Drug:
• Chlorhexidine mouthwash
Chlorhexidine gluconate 0.12% mouthwash is used as intervention in Group A (Arm Group A) for the comparison of plaque reduction among group A and B

Locations

Country	Name	City	State
Pakistan	Liaquat College of Medicine and Dentistry	Karachi	Sindh

Sponsors (2)

Lead Sponsor	Collaborator
Liaquat National Hospital & Medical College	Liaquat College of Medicine and Dentostry

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Dental Plaque	primary outcome is to assessed the reduction on plaque level among Group A and Group B	reduction of plaque index will be assessed on 7th day, 14th day and on 21st day