Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals

Status Terminated

Clinical Trial Summary

The purpose of the study is to assess the effect of enzyme containing lozenges on dental plaque accumulation in healthy adults.

Clinical Trial Description

The purpose of the study is to examine the clinical effects of lozenges containing three extracellular matrix-degrading enzymes on dental plaque accumulation and removal, prevention of gingivitis, and oral microbiome composition after professional tooth cleaning, as compared to a placebo lozenge without enzymes. Two different concentrations of the enzymes will be tested, to investigate a potential dose-dependent effect of the enzymes. Furthermore, safety of the enzyme lozenge will be assessed by clinical evaluation of the oral mucosa. The null hypothesis is that treatment with enzyme-containing lozenges does not affect plaque accumulation as compared to a placebo control. ;

Study Design

Related Conditions & MeSH terms

Dental Plaque

Clinical Trial Details

NCT number	NCT05082103
Study type	Interventional
Source	Novozymes A/S
Contact
Status	Terminated
Phase	N/A
Start date	September 15, 2021
Completion date	March 31, 2022

View Details

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