Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans

Dental Plaque Clinical Trial

Official title:

Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans in Students of the Faculty of Dentistry in the Year 2018

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04485520
• Other study ID #: 00140
• Status: Completed
• Phase: N/A
• Start date: September 21, 2017
• Est. completion date: October 21, 2017

Study information

• Verified date: August 2021
• Source: Universidad Nacional de Caaguazu
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Papaya has effects on oral pathogenic microorganisms, it also has anticoagulant quality, amebicidal action, antimicrobial, bacteriostatic and antifungal activity on different bacteria, especially on Streptococcus mutans, this can be exploited in the dental area. The objective of the study was to determine the efficacy of Carica Papaya peel extract (suckling) as an inhibitor of Streptococcus Mutans in students of the dental faculty of the National University of Caaguazú in 2018.

Description:

Specific objectives

• To determine the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on Streptococcus Mutans by age and sex grouping.

• To quantify the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on the growth of Streptococcus Mutans before, at 10 minutes and 8 days of use in the experimental group.

• Quantify the inhibition of 0.12% Chlorhexidine Gluconate on the growth of Streptococcus Mutans before, after 10 minutes and 8 days of use in the control group.

• Compare the count of Colony Forming Units (CFU) between both groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: October 21, 2017
• Est. primary completion date: October 21, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Participants that signed the informed consent

Exclusion Criteria:

• allergic to carica papaya

• ongoing medical or dental treatment that could interfere with the results.

Related Conditions & MeSH terms

• Dental Plaque
• Streptococcus, Other Specified Group

Intervention

Other:
• CARICA PAPAYA MOUTHWASH
Each application was 10 ml. applied for 1 minute, once a day for 8 days
• CHLORHEXIDINE MOUTHWASH
Each application was 10 ml. applied for 1 minute, once a day for 8 days

Locations

Country	Name	City	State
Paraguay	Facultad de Odontología Universidad Nacional de Caaguazú	Coronel Oviedo	International

Sponsors (1)

Lead Sponsor	Collaborator
Julieta María Méndez Romero

Country where clinical trial is conducted

Paraguay, 

References & Publications (1)

Saliasi I, Llodra JC, Bravo M, Tramini P, Dussart C, Viennot S, Carrouel F. Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial. Int J Environ Res Public Health. 2018 Nov 27;15(12). pii: E2660. doi: 10.3390/ijerph15122660. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of Colony Forming units (Stage 1)	Before Intervention	thorough study completion, an average of 24 hours
Primary	Number of Colony Forming units (Stage 2)	After Intervention	10 minutes after mouthwash use
Primary	Number of Colony Forming units (Stage 3)	After Intervention	8 days after mouthwash use

External Links

•   Zaragoza MT, Benitez V. Actividad antimicrobiana del Papacárie® contra Streptococcus Mutans asilado de saliva. Odonto Pediatr [Internet]. 2012;1(3):18-22.