Dementia Clinical Trial
Official title:
Effect of Musical Intervention Based on Piano Learning on Alzheimer's Patients in León (España).
The goal of this clinical trial is to learn about and describe how pianistic training influences the development of Alzheimer's disease. The key question is: Can pianistic practice influence the development of Alzheimer's disease? Participants will receive piano lessons for 4 weeks (20 sessions) and we will evaluate the evolution of the different parameters described by the tests carried out.
Status | Not yet recruiting |
Enrollment | 20 |
Est. completion date | June 1, 2025 |
Est. primary completion date | August 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years to 90 Years |
Eligibility | Inclusion Criteria: - Patients in State of global deterioration Levels GDS 2 3 and 4. Exclusion Criteria: - Other patients in GDS groups (not 2, 3 and 4) - The selected subject does not cooperate during intervention. |
Country | Name | City | State |
---|---|---|---|
Spain | Universidad de León | León | Castilla Y León |
Lead Sponsor | Collaborator |
---|---|
David Franco Castellanos | Javier Tejada Garcia, Jesús Ángel Seco Calvo |
Spain,
Alzheimer´s Association. (2020). 2020 Alzheimer´s Disease Facts and Figures. Alzheimer´s & Dementia: The Journal of the Alzheimer Association, 16(3), 391-460. Doi: 10.1002/alz.12068
Baird A, Samson S. Memory for music in Alzheimer's disease: unforgettable? Neuropsychol Rev. 2009 Mar;19(1):85-101. doi: 10.1007/s11065-009-9085-2. Epub 2009 Feb 13. — View Citation
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994 Dec;44(12):2308-14. doi: 10.1212/wnl.44.12.2308. — View Citation
Hanna-Pladdy B, MacKay A. The relation between instrumental musical activity and cognitive aging. Neuropsychology. 2011 May;25(3):378-86. doi: 10.1037/a0021895. — View Citation
López O, Tratamiento farmacológico de la enfermedad de Alzheimer y otras demencias. (2015) Recuperado de: http://www.scielo.edu.uy/scielo.php?pid=S1688-423X2015000200003&script=sci_arttext&tlng=pt
Maurer K, Maurer U. Alzheimer. La vida de un médico, la historia de una enfermedad. Madrid: Díaz de Santos; 2006.
MSCBS. Ministerio de Sanidad, Consumo y Bienestar Social (2019) Plan integral de Alzheimer y otras Demencias (2019-2023) Recuperado de: https://mscbs.gob.es/profesionales/saludPublica/docs/Plan_Integral_Alzheimer_Octubre_2019.pdf
NINDS. National Institute of Neurological Disorders and Stroke. (2019). Recuperado de: https://www.ninds.nih.gov/Disorders/All-Disorders/Alzheimers-Disease Information-Page
Paxinos, G. y Mai, J. (2004). The human nervous system. Academic Press, Inc.
Peretz I, Zatorre RJ. Brain organization for music processing. Annu Rev Psychol. 2005;56:89-114. doi: 10.1146/annurev.psych.56.091103.070225. — View Citation
Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Alzheimer's disease. Lancet. 2016 Jul 30;388(10043):505-17. doi: 10.1016/S0140-6736(15)01124-1. Epub 2016 Feb 24. — View Citation
Sclan S, Saillon A, Franssen E, et al. The behavior pathology in Alzheimer's disease ratings scale (BEHAVE-AD): reability and analisys of symptom category scores. Int J Geriatr Psychiatry, 1996; 11: 819-830.
Sultzer DL, Levin HS, Mahler ME, High WM, Cummings JL. Assessment of cognitive, psychiatric, and behavioral disturbances in patients with dementia: the Neurobehavioral Rating Scale. J Am Geriatr Soc. 1992 Jun;40(6):549-55. doi: 10.1111/j.1532-5415.1992.tb02101.x. — View Citation
Tariot PN, Mack JL, Patterson MB, Edland SD, Weiner MF, Fillenbaum G, Blazina L, Teri L, Rubin E, Mortimer JA, et al. The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease. Am J Psychiatry. 1995 Sep;152(9):1349-57. doi: 10.1176/ajp.152.9.1349. — View Citation
Valenzuela MJ, Sachdev P. Brain reserve and dementia: a systematic review. Psychol Med. 2006 Apr;36(4):441-54. doi: 10.1017/S0033291705006264. Epub 2005 Oct 6. — View Citation
* Note: There are 15 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | State of global deterioration | GDS 1 - 7 | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. | |
Primary | Minimental Test | 0-24 | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. | |
Primary | RDRS-2 Rapid Disability Assessment Scale | 18-72 | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. | |
Primary | MONTREAL COGNITIVE ASSESSMENT (MOCA) | 0-30 | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. | |
Primary | WAIS-IV | 0-160 | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. | |
Primary | Behavioral disorders: BEHAVE-AD | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. | ||
Primary | NPI - CUMMINGS | 0-120 | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. | |
Primary | Evaluation of the caregiver's burden (Zarit test) | 0-88 | Pre-intervention, Post-intervention (after four weeks of intervention), Follow up after 6 month intervention. |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05686486 -
Gentle Gymnastics and Relationship Between Family Caregivers and Residents With Dementia in Nursing Homes
|
N/A | |
Terminated |
NCT05451693 -
Outreach-ER: A Dementia Care Intervention Program
|
||
Recruiting |
NCT05820919 -
Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
|
N/A | |
Enrolling by invitation |
NCT06040294 -
Dementia and Disability Simulation for College Nursing Students' Senior Activity Facilitation Skills
|
N/A | |
Completed |
NCT05114187 -
An Internet-Based Education Program for Care Partners of People Living With Dementia
|
N/A | |
Recruiting |
NCT06322121 -
Vascular Aspects in Dementia: Part 2
|
||
Active, not recruiting |
NCT03676881 -
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease
|
||
Completed |
NCT04426838 -
Cognitive Behavioral Therapy for Insomnia for the Dementia Caregiving Dyad
|
N/A | |
Recruiting |
NCT03462485 -
Pilot Study of the Effects of Playing Golf on People With Dementia
|
N/A | |
Active, not recruiting |
NCT03677284 -
Managing Time With Dementia: Effects of Time Assistive Products in People With Dementia
|
N/A | |
Completed |
NCT03849937 -
Changing Talk Online (CHATO) Study
|
N/A | |
Recruiting |
NCT06284213 -
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
|
||
Recruiting |
NCT05579236 -
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
|
||
Completed |
NCT05080777 -
Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems
|
N/A | |
Completed |
NCT04571697 -
A Study of Comparing Rates of Dementia and Alzheimer's Disease in Participants Initiating Methotrexate Versus Those Initiating Anti-tumor Necrosis Factor (TNF)-Alpha Therapy
|
||
Completed |
NCT03583879 -
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
|
N/A | |
Recruiting |
NCT06033066 -
Financial Incentives and Recruitment to the APT Webstudy
|
N/A | |
Active, not recruiting |
NCT05204940 -
Longitudinal Observational Biomarker Study
|
||
Recruiting |
NCT05684783 -
Dementia Champions in Homecare
|
||
Completed |
NCT03147222 -
Function Focused Care: Fracture Care at Home
|
N/A |