Fine and Gross Motor Function and Relationship With Muscle Tone in Older Adults With and Without Dementia

Dementia Clinical Trial

Official title:

Fine and Gross Motor Function and Relationship With Muscle Tone in Older Adults With and Without Dementia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03479567
• Other study ID #: EC/2014/1240
• Status: Completed
• Phase: N/A
• Start date: January 2015
• Est. completion date: December 2017

Study information

• Verified date: December 2023
• Source: University Ghent
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was (1) to investigate changes in gait, balance, fine motor function, and muscle tone, and (2) to find out if there is a correlation between muscle tone/presence of paratonia and motor function (gross and fine) in mild and moderate dementia.Three groups of participants were included in the study: healthy elderly (n=60), participants with mild dementia (n=31) and participants with moderate dementia (n=31). Measurements of fine motor function, balance, gait, presence of paratonia and muscle tone measurements were performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 122
• Est. completion date: December 2017
• Est. primary completion date: December 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• age >= 65 years
• walk independently for at least 11 meters
• HC: no cognitive deterioration, MiD: dementia, Global Deterioration Scale<5, MoD:

dementia, Global Deterioration Scale 5 or 6

Exclusion Criteria:

• recent (= 6 months) orthopedic surgery

Related Conditions & MeSH terms

• Balance
• Dementia
• Fine Motor Function
• Gait
• Muscle Tone
• Paratonia

Intervention

Other:
• Gait accelerometry
accelerometric assessment of gait (Dynaport Hybrid): 7m walk in 3 conditions (normal pace, fast, double task)
• balance accelerometry
accelerometric assessment of balance (Dynaport Hybrid) during 10 seconds trial in 3 conditions (side-by-side, semitandem, tandem)
• Fine motor skill test
assessment of fine motor skills with Purdue Pegboard, with dominant hand, non-dominant hand and bimanual

Diagnostic Test:
• Paratonia Assessment Instrument (PAI)
diagnosis of paratonia based on passive movement of the four limbs

Other:
• myotonometric measurement of muscle tone
MyotonPRO measurement of muscle tone

Locations

Country	Name	City	State
Belgium	Vakgroep Revaki - Ghent University	Ghent

Sponsors (1)

Lead Sponsor	Collaborator
University Ghent

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	walking speed	gait speed parameter	through study completion, an average of 3 years
Primary	step regularity	gait parameter representing regularity, autocorrelation (method Moe-Nilssen 2004), value between 0 and 1, with 1 representing perfect regularity	through study completion, an average of 3 years
Primary	mediolateral jerk	balance smoothness and coordination, lower jerk values correspond with better smoothness of balance	through study completion, an average of 3 years
Primary	anteroposterior jerk	balance smoothness and coordination, lower jerk values correspond with better smoothness of balance	through study completion, an average of 3 years
Primary	Fine motor function	score on the Purdue pegboard test, maximal amount of (pairs of) pegs placed in 30 seconds (max. 25)	through study completion, an average of 3 years
Primary	presence of paratonia	Paratonia Assessment Instrument, resistance against passive movements of the four limbs is evaluated (Hobbelen 2008)	through study completion, an average of 3 years
Primary	MyotonPRO measurement of muscle tone	MyotonPRO measurement	through study completion, an average of 3 years
Secondary	MyotonPRO measurement of elasticity	MyotonPRO measurement	through study completion, an average of 3 years
Secondary	MyotonPRO measurement of mechanical stiffness	MyotonPRO measurement	through study completion, an average of 3 years