Enhanced CJD Surveillance in the Older Population

Dementia Clinical Trial

Official title: Enhanced CJD Surveillance in the Older Population

Status Recruiting

Clinical Trial Summary

The purpose of this study to investigate if cases of Creutzfeldt-Jakob Disease (CJD) and other forms of prion disease are being missed in older adults living within Lothian.

Clinical Trial Description

The study involves patients aged 65 years or over who have been seen by a neurologist or psycho-geriatrician and identified as having features that are atypical for the known types of dementia. All patients will be invited to an initial meeting with the research team to discuss the study and, if they agree to participate, for clinical assessment and epidemiological review. Participants will be asked to donate blood or a buccal sample for codon-129 polymorphism genotyping and may be offered a MRI brain scan if no such imaging has been previously undertaken. Participants will also be asked to consider if, in the event of their death, they would donate samples of brain tissue to the Edinburgh Brain Bank for use in this and future research. Telephone follow up will be offered within 1 month of joining the study and at 3 monthly intervals thereafter, with further clinical review offered if deemed appropriate. ;

Related Conditions & MeSH terms

• Dementia
• Prion Disease
• Prion Diseases

• NCT number: NCT02629640
• Study type: Observational
• Source: University of Edinburgh
• Contact: Lovney Kanguru
• Phone: 0131 537 2128
• Email: Lovney.Kanguru@ed.ac.uk
• Status: Recruiting
• Start date: January 2016
• Completion date: March 2020