Enhanced CJD Surveillance in the Older Population

Status Completed

Clinical Trial Summary

The purpose of this study to investigate if cases of Creutzfeldt-Jakob Disease (CJD) and other forms of prion disease are being missed in older adults living within Lothian.

Clinical Trial Description

The study involves patients aged 65 years or over who have been seen by a neurologist or psycho-geriatrician and identified as having features that are atypical for the known types of dementia. All patients will be invited to an initial meeting with the research team to discuss the study and, if they agree to participate, for clinical assessment and epidemiological review. Participants will be asked to donate blood or a buccal sample for codon-129 polymorphism genotyping and may be offered a MRI brain scan if no such imaging has been previously undertaken. Participants will also be asked to consider if, in the event of their death, they would donate samples of brain tissue to the Edinburgh Brain Bank for use in this and future research. Telephone follow up will be offered within 1 month of joining the study and at 3 monthly intervals thereafter, with further clinical review offered if deemed appropriate. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02629640
Study type	Observational
Source	University of Edinburgh
Contact
Status	Completed
Phase
Start date	January 19, 2016
Completion date	March 31, 2022

View Details

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