Porphyromonas Gingivalis and Alzheimer's Disease

Dementia Clinical Trial

— PGNEURO  

Official title:

Porphyromonas Gingivalis - a Responsible Pathogen in Alzheimer's Disease?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02109705
• Other study ID #: PG001
• Status: Completed
• Start date: March 2014
• Est. completion date: January 2021

Study information

• Verified date: December 2014
• Source: University Hospital Muenster
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

With this study the investigators would like to analyze the the role of periodontal disease and especially the role of Porphyromonas gingivalis in initiation and progression of Alzheimer's Disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: January 2021
• Est. primary completion date: January 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 40 Years to 70 Years

Eligibility

Inclusion Criteria:

• age 40-70

• caucasian origin

• dementia (Alzheimer's or other dementia)

• cognitive healthy (need for spinal anesthesia)

Exclusion Criteria:

• use of antibiotics within las 6 months

• pregnancy

• another illness explaining the symptoms in a better way

• smoking (>10 cigarettes)

• patients who have a legal custodian

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease
• Dementia
• Periodontitis

Locations

Country	Name	City	State
Germany	Department of Periodontology	Muenster

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital Muenster	University of Bern

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Cmax: Periodontal pathogens	laboratory analysis	Baseline
Other	U enzyme activities	laboratory analysis	Baseline
Other	Cmax: inflammatory cytokines	laboratory analysis	Baseline
Primary	Cmax Antibody Levels against Gingipains	laboratory analysis	Baseline
Secondary	Cmax Beta-Amyloid	laboratory analysis	Baseline