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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02109705
Other study ID # PG001
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 2014
Est. completion date January 2021

Study information

Verified date December 2014
Source University Hospital Muenster
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

With this study the investigators would like to analyze the the role of periodontal disease and especially the role of Porphyromonas gingivalis in initiation and progression of Alzheimer's Disease.


Recruitment information / eligibility

Status Completed
Enrollment 90
Est. completion date January 2021
Est. primary completion date January 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 40 Years to 70 Years
Eligibility Inclusion Criteria: - age 40-70 - caucasian origin - dementia (Alzheimer's or other dementia) - cognitive healthy (need for spinal anesthesia) Exclusion Criteria: - use of antibiotics within las 6 months - pregnancy - another illness explaining the symptoms in a better way - smoking (>10 cigarettes) - patients who have a legal custodian

Study Design


Locations

Country Name City State
Germany Department of Periodontology Muenster

Sponsors (2)

Lead Sponsor Collaborator
University Hospital Muenster University of Bern

Country where clinical trial is conducted

Germany, 

Outcome

Type Measure Description Time frame Safety issue
Other Cmax: Periodontal pathogens laboratory analysis Baseline
Other U enzyme activities laboratory analysis Baseline
Other Cmax: inflammatory cytokines laboratory analysis Baseline
Primary Cmax Antibody Levels against Gingipains laboratory analysis Baseline
Secondary Cmax Beta-Amyloid laboratory analysis Baseline
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