Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Dementia Clinical Trial

Official title:

Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01738568
• Other study ID #: 12-003357
• Status: Completed
• Phase: N/A
• Start date: October 2012
• Est. completion date: February 12, 2015

Study information

• Verified date: August 2021
• Source: Mayo Clinic
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 27
• Est. completion date: February 12, 2015
• Est. primary completion date: February 12, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible. Pregnant women, children, prisoners or other at risk populations will not be recruited.

Inclusion Criteria:

• Age 18-30 years or 65-80 years

Exclusion Criteria:

• Body mass index (BMI) >31 kg/m2

• Smoking

• Pregnancy

• Participation in structured exercise (>2 times per week for 30 minutes or longer)

• Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease

• Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise

• Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)

• Claustrophobia

Related Conditions & MeSH terms

• Dementia

Intervention

Behavioral:
• High intensity aerobic training
High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at ~70-95% maximum workload for 4 minutes followed by 3 minutes of rest.
• Sedentary Control
Sedentary control participants will not perform any regular exercise for 12-weeks.

Locations

Country	Name	City	State
United States	Mayo Clinic in Rochester	Rochester	Minnesota

Sponsors (1)

Lead Sponsor	Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Brain Glucose Uptake	The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.	12 weeks

External Links

•   Mayo Clinic Clinical Trials