Dementia Clinical Trial
Patients will be followed every 6 months for a total of 5 visits (Month 0, 6, 12, 18 and
24). The first visit is the screening and entry visit which can occur at any time after the
subject finishes SEARCH 001 study but preferably it should occur approximately 6 months
after SEARCH 001 study completion.
At each visit, patients will undergo the following
1. Assessment of function including activity of daily living questionnaire
2. History of medical illnesses, medication history
3. Neurological examination: All patients will have a neurological evaluation and
neuropsychological evaluation to characterize neurocognitive and neurological status.
(It is possible that patients within the non-dementia group will meet criteria for
dementia after close testing is completed).
4. Neuropsychological assessment:
5. Thai Depression Inventory.
6. HIV viral load and storage of blood for proviral DNA level
Final outcome assessment based on all available data. If possible, it is intended that these
diagnoses will be determined through monthly VTC conference calls with UH investigators.
This consensus conference will include the Thai investigators, the UH neurologist, the UH
neuropsychologist and the UH principal investigators.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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