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Terazosin for Dementia With Lewy Bodies — TZ-DLB  

Dementia With Lewy Bodies Clinical Trial

Official title:
a Randomized, Double Blind, Placebo Controlled Clinical Trial Exploring the Target Engagement and Tolerability of Terazosin Hydrochloride in Patients With Dementia With Lewy Bodies

Clinical Trial Summary

The TZ-DLB trial will be a 3:2 (active:placebo) randomized, double-blind, placebo-controlled Pilot trial to evaluate the tolerability of terazosin for the treatment of dementia with Lewy bodies.

Clinical Trial Description

This will be a single center, randomized, double-blind, placebo-controlled, pilot study to assess the tolerability of terazosin (TZ) at 1 and 5 milligrams (MG) daily for patients with DLB. The primary goal of this study is to assess the tolerability of TZ in patients with DLB. This is a pilot study and is not powered to assess efficacy of this medication. Our hope is that this study will guide future studies of this (and similar) medications for the disease modification of DLB. This study is also aimed to learn more about how patients with produce and use energy and if TZ can help to reverse energy deficits that appear in DLB. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04760860
Study type Interventional
Source University of Iowa
Contact qiang zhang, MD
Phone 4154251369
Email qiang-zhang@uiowa.edu
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date October 2024
Completion date December 2026
View Details
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