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Dementia Severe clinical trials

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NCT ID: NCT05612711 Not yet recruiting - Behavioral Symptoms Clinical Trials

Dronabinol for Agitation in Dementia Crossover Trial

Start date: November 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to study the effects of dronabinol in US Veterans with agitation related to moderate to severe dementia. The main goals of the study are: - To evaluate the efficacy of dronabinol for the treatment of agitation in moderate to severe dementia compared to placebo - To evaluate the safety of dronabinol in the treatment of agitation in moderate to severe dementia compared to placebo Fifty (50) subjects will be given either dronabinol or placebo for 8 weeks. All subjects will then undergo a "washout" phase for 3 weeks, followed by the crossover intervention (i.e. subjects who received placebo during the first phase will receive dronabinol during the second phase, and vice versa). Thus, all participants will be taking dronabinol at some point during the study. During the study, subjects will undergo evaluations for: - Agitation - Cognitive changes - Physical changes (i.e. labs, ekg, physical exam)

NCT ID: NCT05165186 Recruiting - Dementia Clinical Trials

Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions

Start date: April 13, 2022
Phase: N/A
Study type: Interventional

The overall objective of this study is to compare knowledge, decisional conflict, preferences, and caregiver burden over time caregivers of Alzheimer's Disease and Related Dementias (ADRD) patients by comparing the effectiveness of a video decision aid intervention and enhanced usual care.

NCT ID: NCT04948866 Enrolling by invitation - Alzheimer Disease Clinical Trials

Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers

ADRD-PC
Start date: July 26, 2021
Phase: N/A
Study type: Interventional

Millions of Americans have late-stage Alzheimer's and related dementias (ADRD), causing suffering due to loss of awareness of self and family, progressive dependency, physical and neuropsychiatric symptoms, and physical, emotional and financial strain for caregivers. Investigators now propose a multi-site randomized clinical trial of the ADRD Palliative Care (ADRD-PC) program for persons with late-stage ADRD and their family caregivers, triggered during hospitalization. Investigators aim to learn if this program of dementia-specific palliative care, standardized caregiver education, and transitional care is effective to reduce burdensome hospital transfers, improve symptom treatment and control, augment supportive services, and reduce nursing home transitions for patients, and to improve caregiver outcomes of communication, shared decision-making and distress.

NCT ID: NCT04863859 Recruiting - Dementia Clinical Trials

Persons With Dementia and Their Extended Family Caregivers

CareEx
Start date: September 11, 2021
Phase:
Study type: Observational

Immediate family members shoulder the majority of care responsibilities for persons living with dementia. However, due to various societal changes, elder care responsibilities have expanded to extended family members, including grandchildren, siblings, nieces/nephews, siblings, and step-kin. The main objective of this study is to understand the caregiving journeys of various extended family members involved in dementia care. We aim to learn about caregivers' care management strategies; their use of home and community-based services and informal support; and barriers to service usage. We will use the results from the study to help enhance service delivery, alleviate care-related stress, and improve the quality of life of dementia patients and their caregivers. We will use a mixed-methods design to explore the challenges faced by caregivers as well as their service usage for the person living with dementia. Our methodology involves an initial telephone interview (approx. 70 minutes) that includes open-ended questions, standard items, and structured measures, followed by an 8-day semi-structured daily diary interview about daily care responsibilities and experiences with services (15-20 minutes each evening). This study will be conducted with 240 extended family members serving as one of the main caregivers for a person living with dementia in a community setting.

NCT ID: NCT04555629 Not yet recruiting - Dementia Clinical Trials

Advanced Cognitive Stimulation Therapy Hong Kong (ACST-HK)

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

This study is a feasibility randomized controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia in Hong Kong. The psychosocial intervention is adapted from Cognitive Stimulation Therapy (CST), translated and adapted for the Hong Kong Chinese population, and developed within the Medical Research Council (MRC) framework.

NCT ID: NCT04550975 Not yet recruiting - Dementia Clinical Trials

Advanced Cognitive Stimulation Therapy (ACST)

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

This study is a feasibility randomised controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia. The psychosocial intervention is adapted from Cognitive Stimulation Therapy (CST) and developed within the Medical Research Council (MRC) framework.