Clinical Trials Logo

Clinical Trial Summary

This research investigates the effect of active versus sham tACS paired with cognitive exercises in a regimen protocol of weeks, everyday. The study design is a one-time crossing over design in which participants are randomized into two groups: One group will receive active treatment for 4 weeks, then 8 weeks of no treatment followed by another 4 weeks of treatment but with sham. The other group will start with sham and end up with active treatment. The study is double-blind; thus, neither participants, nor the assessors know the group assignment. The Intervention is applying tACS either active or sham paired with cognitive exercises (MindTriggers app games). Note: The above study will run at both University of Manitoba (U of M) and Aster Gardens residence. However, at Aster Gardens Residence only questionnaire type of assessments will be run, while in U of M, the investigators will have three other major assessments as well. In addition, the investigators will run the assessments at the Aster Gardens Residence through online sessions.

Clinical Trial Description

This research will investigate the effect of applying transcranial alternating current stimulation (tACS) when paired with cognitive exercises on older adults in a placebo-controlled double-blind study with statistical rigor. In addition, the investigators will investigate and explore novel technological methods not only to monitor the plausible changes due to intervention but also to predict the response of a participant to the intervention at baseline. Since most technological intervention on dementia have a demanding and costly protocol, it would be of great interest to have a reliable prediction of a participant to a treatment at baseline; that would lead to personalized optimum treatment strategy. The investigators will use Electrovestibulography (EVestG), Egocentric Spatial Assessment using our Virtual Reality Navigation (VRN) and functional near infrared spectroscopy (fNIRS) measurements and analysis to develop the monitoring and predicting technologies. EVestG is a non-invasive measure of the vestibuloacoustic system in both background (no motion) and in response to passive whole-body tilt stimuli. The investigators hypothesize there is a direct link between vestibular system deficiencies and Alzheimer's. VRN measures how people orient themselves in a non-familiar environment; the investigators hypothesize it is deteriorated significantly in Alzheimer's even at its onset. fNIRS measures oxygenated and deoxygenated blood flow to the brain and it may help to understand neuronal changes due to intervention. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05203523
Study type Interventional
Source University of Manitoba
Status Recruiting
Phase N/A
Start date January 24, 2022
Completion date November 1, 2024

See also
  Status Clinical Trial Phase
Completed NCT03692988 - Dignity Therapy for Patients With Early Dementia and Their Family N/A
Enrolling by invitation NCT03772977 - The Brain Health Champion Study N/A
Active, not recruiting NCT03661034 - Study of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Function (Etude Study) N/A
Not yet recruiting NCT04942184 - STRATEGIES to Improve Memory in Alzheimer's Disease N/A
Recruiting NCT05343611 - Chocolate and Physical Exercise to Reduce Malnutrition in Pre-dementia Aged People N/A
Recruiting NCT05187117 - CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners N/A
Recruiting NCT05102201 - Effect of the Group-based Paro Intervention on Physiological and Psychological Outcomes N/A
Recruiting NCT04313582 - Feasibility of the SmartPrompt for Improving Everyday Function in Dementia N/A
Completed NCT05240664 - Effects of An ACP Programme for Older People With Early Dementia N/A
Completed NCT03384043 - Comparing Smartphone Technology and a Memory Strategy on Improving Prospective Memory in Alzheimer's Disease N/A
Recruiting NCT04315337 - Improving Everyday Task Performance Through Repeated Practice in Virtual Reality. N/A
Recruiting NCT04531956 - Implementation of a Diagnostic Decision-aid for People With Memory Complaints and Their General Practitioners N/A
Completed NCT02350738 - Effects of Multimodal Cognitive Enhancement Therapy (MCET) for Ealy Dementia Phase 3
Active, not recruiting NCT04950998 - Smartphone App to Improve Physical Activity in Older Adults With MCI/Mild Dementia N/A
Completed NCT03246269 - Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
Recruiting NCT05023564 - PUMCH Dementia Longitudinal Cohort Study
Recruiting NCT03536975 - Identify the Benefits CAREGIVERSPRO-MMD Platform Use Based on the Information and Communications Technology, Dedicated to the Support and Assistance of Dyads Living With Neurocognitive Diseases and Their Primary Caregivers N/A
Completed NCT04648735 - Driving Evaluation and Fitness for Persons With Cognitive Impairments N/A
Active, not recruiting NCT03556280 - Multi-Center Study of Sensory Stimulation to Improve Brain Function N/A
Recruiting NCT05165186 - Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions N/A