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NCT ID: NCT04358627 Not yet recruiting - Inflammation Clinical Trials

Dexmedetomidine to Improve Outcomes of ARDS in Critical Care COVID-19 Patients

COVID-DEX
Start date: April 15, 2020
Phase:
Study type: Observational

A continuous infusion of Dexmedetomidine (DEX) will be administered to 80 patients admitted to Critical Care because of signs of Respiratory Insufficiency requiring non-invasive ventilation. Measurements of respiratory performance and quantification of cellular and molecular inflammatory mediators. The primary outcome will be the avoidance of mechanical ventilation with secondary outcomes duration of mechanical ventilation, avoidance of delirium after sedation and association of mediators of inflammation to outcomes. Outcomes will be compared to a matched historical control (no DEX) series