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Deleterious BRCA2 Gene Mutation clinical trials

View clinical trials related to Deleterious BRCA2 Gene Mutation.

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NCT ID: NCT03845296 Active, not recruiting - Clinical trials for Stage IV Lung Cancer AJCC v8

Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Start date: April 16, 2019
Phase: Phase 2
Study type: Interventional

This phase II Lung-MAP trial studies how well rucaparib works in treating patients with genomic loss of heterozygosity (LOH) high and/or deleterious BRCA1/2 mutation stage IV non-small cell lung cancer or that has come back. Rucaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

NCT ID: NCT03586661 Active, not recruiting - Clinical trials for Recurrent Ovarian Carcinoma

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Start date: April 29, 2019
Phase: Phase 1
Study type: Interventional

This phase Ib trial studies the best dose and side effects of niraparib and copanlisib in treating patients with endometrial, ovarian, primary peritoneal, or fallopian tube cancer that has come back. Niraparib and copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

NCT ID: NCT03546972 Active, not recruiting - Obesity Clinical Trials

Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants

Start date: December 17, 2017
Phase: N/A
Study type: Interventional

This pilot trial studies how well a diabetes prevention program with or without hunger training works in helping to lower breast cancer risk in obese participants. A diabetes prevention program involves learning about and receiving materials on different strategies to encourage weight loss, and hunger training involves learning how to recognize hunger. It is not yet known whether adding hunger training to a diabetes prevention program helps participants control their weight that could reduce the risk of some cancers.

NCT ID: NCT02760849 Active, not recruiting - Clinical trials for Hereditary Breast and Ovarian Cancer Syndrome

Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations

Start date: May 2, 2016
Phase: N/A
Study type: Interventional

This phase II trial studies how well surgery works in preventing ovarian cancer in patients with genetic mutations at risk of ovarian cancer. Risk reducing salpingo oophorectomy (RRSO) is surgery to remove the fallopian tubes and ovaries at the same time. Interval salpingectomy with delayed oophorectomy (ISDO) is surgery to remove the fallopian tubes. It is not known whether ISDO works better than RRSO at lowering risk of ovarian cancer and improving the sexual function and psychosocial well-being in patients with genetic mutation.