Dehydration, Diverting Ileostomy, Loperamide Clinical Trial
Official title:
Prospective Randomized Control Study on Effect of Post Operative Loperamide in Decreasing Readmission for Dehydration in Colorectal Patients After Diverting Ileostomies
Dehydration post creation of a diverting ileostomy is a common and debilitating problem faced
by patients undergoing ileal-anal pouch anastomoses for both inflammatory bowel disease and
familial adenomatous polyposis (FAP) syndrome. Those patients with low rectal cancers or
other polyposis syndromes e.g. HNPCC hereditary non polyposis colorectal cancers, may
potentially have a delay in the adjuvant therapy when faced with this complication.
Studies performed in this groups of patients report a readmission rate of 17-21% for
dehydration.
Loperamide has been shown to significantly decrease the daily volume of weight of stool in
these patients.
The purpose of this study is to establish whether loperamide given at 4mg three times daily
for 14 days from day of discharge empirically decreases 30 days readmission rate for
dehydration.
The investigators hypothesize that there will be a 15% decrease from 25% to 10% in the
readmission rates, that severity of dehydration will be decreased.
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