ACHAT-STUDY, Alternative Treatment of Chronic Globus Sensations

Status Completed

Clinical Trial Summary

Globus sensations are associated with gastroesophageal reflux disease as well as the presence of a gastric inlet patch. No controlled trial exists on whether ablation of the cervical heterotopic mucosa may lead to improvement of chronic globus sensations. The aim of this sham-controlled trial is to clarify whether argon-beamer-ablation of cervical heterotopic gastric inlet patches of the esophagus improves patients' chronic globus sensations.

Clinical Trial Description

Some data suggest that ablation of gastric inlet patches by argon beamer therapy might lead to alleviation of chronic globus sensation or sore throat. Acid reflux or its treatment is unlikely to influence these results (Meining et al. Argon plasma ablation of gastric inlet patches in the cervical esophagus may alleviate globus sensation: a pilot trial. Endoscopy. 2006 Jun;38(6):566-70). Within the present study we will perform a randomized, sham-controlled and blinded trial, where patients with heterotopic gastric mucosa (HGM) of the cervical esophagus and globus sensations (a chronic or intermittent lump in the throat for at least 3 months) are going to be randomized after histological verification of HGM in the study center (Technical University Clinic Munich). Either a beamer ablation of HGM or a sham-therapy will be performed after patients complete a validated questionnaire. Patients are blinded for 3 months, then after completing another questionnaire endoscopy is repeated. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00439439
Study type	Interventional
Source	Technische Universität München
Contact
Status	Completed
Phase	N/A
Start date	October 2006
Completion date	May 2008

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06445309` - Design and Development of a Functional Plant-based Beverage Formulated According to the Main Nutritional Guides for Early Elderly Requirements to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
Completed	`NCT00570557` - Development of a Web-Based Course to Maintain Skills in Nurses Trained to Screen for Dysphagia	N/A
Completed	`NCT04243577` - Wearable Monitoring Systems for Swallowing Function and Disorders	Early Phase 1
Recruiting	`NCT03975465` - EMST and Swallowing in Long-Term Survivors of HNCA	N/A
Completed	`NCT05013918` - Oral Health and Nutrition Integrated Care Model
Recruiting	`NCT05439447` - A Study on Building a Voice Cohort for the Development of a Non-face-to-face Machine Learning Diagnostic and Monitoring Platform Using Voice Analysis and Various Sensors in Patients With Dysphagia.
Recruiting	`NCT05149976` - Establishment of Voice Analysis Cohort for Development of Monitoring Technology for Dysphagia
Recruiting	`NCT05978700` - Effectiveness of Video-game Based Swallowing Function Training in Patients With Dysphagia	N/A
Recruiting	`NCT06219200` - Automatic Voice Analysis for Dysphagia Screening in Neurological Patients
Enrolling by invitation	`NCT02935946` - Cold Liquids Fed to Preterm Infants: Efficacy and Safety After 10 Minutes of Exposure	N/A
Withdrawn	`NCT02925507` - Computerized Acoustic Swallowing Evaluation	N/A
Completed	`NCT02379182` - Effect Of Vitalstim In Patients With Chronic Post-stroke Oropharyngeal Dysphagia	N/A
Completed	`NCT02457052` - Impact of a Transportable Customizable and Scalable Sitting Positioning Device on Swallowing Disorders	N/A
Completed	`NCT02825927` - Swallowing Function, Oral Health, and Food Intake in Old Age	N/A
Active, not recruiting	`NCT01559649` - Stroke Swallowing Screening Tool Validation	N/A
Completed	`NCT00141752` - Toronto Bedside Swallowing Screening Test (TOR-BSST) - A Bedside Swallowing Screening for Stroke Patients	N/A
Completed	`NCT04369092` - Myotonometer Analyses of Muscles in Multiple Sclerosis Patients With Dysphagia	N/A
Recruiting	`NCT06465355` - Effects of an Air Bolus on Primary Peristalsis	N/A
Terminated	`NCT02576470` - Motor Learning in Dysphagia Rehabilitation	N/A
Completed	`NCT02003287` - Comparing FEES to VFSS in Diagnosing Laryngeal Penetration and Aspiration in Infants in the NICU	N/A