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Deglutition Disorders clinical trials

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NCT ID: NCT03253354 Recruiting - Parkinson Disease Clinical Trials

Neurostimulation for Dysphagia in Parkinson's Disease

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

This study will explore the effects of 3 different neurostimulation methods on swallowing function in patients with dysphagia secondary to Parkinson's Disease

NCT ID: NCT03247374 Not yet recruiting - Clinical trials for Deglutition Disorders

Bio-feedback Treatment for Dysphagic Post-stroke Patients

Start date: August 14, 2017
Phase: N/A
Study type: Interventional

The primary purpose of the study is to evaluate whether the effect of bio-feedback dysphagia treatment is more effective than a control treatment in post-stroke patients. This study will be a randomized, single-blind controlled pilot study. The investigators intend to recruit 40 patients who have suffered a stroke and have dysphagia. Twenty patients will undergo training with bio-feedback (experimental group) and the other 20 patients will undergo standard training, using only verbal feedback rather than visual feedback (control group). The authors hypothesize that in the control group the efficacy of the treatment will be lower in the absence of immediate visual feedback of strength and coordination of the swallowing act.

NCT ID: NCT03244553 Enrolling by invitation - Dysphagia Clinical Trials

Treatment of Dysphagia and Ineffective Esophageal Motility With Prucalopride: A Pilot Study

Start date: August 2017
Phase: Phase 2
Study type: Interventional

This study will test prucalopride (a prokinetic drug currently approved by Health Canada for treatment of constipation) as a treatment for Ineffective Esophageal Motility (IEM). Adult patients with previously diagnosed IEM will be invited to participate by the investigators. The participants will take the study medication for 5 days and on the final day of medication undergo an esophageal manometry procedure at the Calgary Gut Motility Centre to measure esophageal function. Symptoms and side effects will be tracked at baseline and on Day 5.

NCT ID: NCT03241615 Recruiting - Clinical trials for Neurogenic Dysphagia

Dysphagia Symptom Severity and Quality of Life

Start date: August 8, 2017
Phase: N/A
Study type: Observational

The aim of the study is to investigate the relationship between dysphagia symptom severity and quality of life of the patients with neurogenic dysphagia.

NCT ID: NCT03219346 Recruiting - Stroke Clinical Trials

The Effectiveness of Oral Health in Improving Dysphagia of Patients After Stroke of Swallowing Function and Oral Health Quality of Life

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

The prevalence of chewing dysphagia in the domestic rehabilitation department ward was about 53.61%.Nasal tube retention of about 31%, due to nasogastric tube feeding, often overlooked oral hygiene, easy to cause respiratory tract infection. At the same time, oral hygiene will also affect the effectiveness of swallowing treatment, is worthy of attention to health problems.

NCT ID: NCT03192358 Not yet recruiting - Parkinson Disease Clinical Trials

Physiological Flow of Liquids Used in Dysphagia Management

Start date: September 2017
Phase: N/A
Study type: Observational

For individuals with neurodegenerative conditions, such as Amyotrophic Lateral Sclerosis and Parkinson disease, swallowing impairment (i.e., dysphagia) is a common and serious symptom. Dysphagia places the affected individual at risk for secondary health consequences, including malnutrition and aspiration pneumonia, and negatively affects quality of life. Thickened liquids are commonly recommended for individuals with dysphagia, as they flow more slowly and reduce the risk of entry into the airway. However, there is limited understanding about how changes in liquid thickness modulate swallowing physiology in individuals with neurodegenerative conditions, and previous reports have shown that increased liquid thickness may contribute to the accumulation of residue in the throat. The purpose of this study is to explore swallowing physiology and function in individuals with neurodegenerative conditions, across five levels of liquid thickness (thin, slightly-thick, mildly-thick, moderately-thick, and extremely-thick), and to identify boundaries of "optimal liquid thickness", which maintain airway safety, without contributing to the accumulation of significant residue. Results from this study will help guide the clinical recommendations for thickened liquids in dysphagia management.

NCT ID: NCT03186014 Recruiting - Malignant Dysphagia Clinical Trials

A Fully Covered Irradiation Stent for the Palliation of Malignant Dysphagia

Start date: June 2017
Phase: N/A
Study type: Interventional

Dysphagia is the major symptom of patients with malignant esophageal stricture caused predominantly by advanced esophageal cancer. Stent placement is the most commonly used strategies for relieving the dysphagia and a novel irradiation stent loaded with 125I seeds has recently been developed. A multicentre randomized clinical trial demonstrated this irradiation stent can relieve the dysphagia rapidly and prolong the survival of patients with advanced esophageal cancer, but the total stent stenosis rate cannot be ruduced. A novel fully covered segmented retrievable irradiation stent was developed in our institute. The purpose of this study is to evaluate the safety and clinical efficacy of this newly developed irradiation stent in patients with unresectable malignant dysphagia.

NCT ID: NCT03167892 Recruiting - Clinical trials for Dysphagia, Oropharyngeal

Oral Screens in Post Stroke Training

Start date: September 15, 2017
Phase: N/A
Study type: Interventional

Stroke is a common disease in older people, and often leads to various degrees of disability. Dysphagia is one such consequence which is associated with aspiration pneumonia and malnutrition. There are studies showing that oral screen-training may reduce dysphagia, but the method is insufficiently evaluated. Since treatment with an oral screen is easy, relatively quick and cheap, it is of high relevance to perform a strict and unbiased study to assess the feasibility and efficacy of the intervention. Thus, the aim of the present study is to evaluate the effect of daily oral screen training in post-stroke patients with dysphagia. A randomized controlled clinical study will be performed in subjects who have had a first stroke 8-12 months earlier and suffer from dysphagia. The intervention consists of daily oral screen training for 3 months. In total 70 subjects will be randomized to intervention or control. The changes in swallowing capacity is the main outcome, and secondary outcomes are subjective swallowing problems, lip force, chewing function and quality of life. Improved oral motor function and decreased dysphagia in post-stroke patients will result in an improved quality of life for the individual, and also reduce hospitalization and health care costs.

NCT ID: NCT03163355 Recruiting - Swallowing Disorder Clinical Trials

Comparison of Pureed Rice Using a Gelling Agent and Standard Pureed Rice

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

The texture of the pureed diet is likely to be most useful factor predictive of the prevention of aspiration pneumonia. However, it has not been previously reported what kinds of texture of the pureed diet can prevent aspiration pneumonia. Using endoscopic swallowing evaluation, we attempt to compare two kinds of the pureed diets to choose the better texture of pureed diets in elderly patients with severe dysphagia.

NCT ID: NCT03147755 Completed - Clinical trials for Deglutition Disorders


Start date: May 2010
Phase: N/A
Study type: Observational

Oropharyngeal dysphagia (OD) is a common morbidity after stroke that disrupts swallowing physiology. The investigators aimed at evaluating the prevalence of oropharyngeal dysphagia (OD) after stroke and analysing the risk factors and associated complications.