Degenerative Aortic Valve Stenosis Clinical Trial
Official title:
The Effect of Transaortic Valve Replacement on the Endothelial Integrity and Function
Degenerative aortic valve stenosis (AVS) is the leading cause of aortic valve morbidity with
a prevalence of 2-7% at ages above 65 years, with ever-increasing incidence especially in
the 8th decades. AVS is independently associated with atheroclerosis risk factors and
clinically apparent CV disease indicating that the degeneration of the aortic valve may
represent an atheroclerosis-like process involving both, the aortic valve as well as the
vascular system, respectivel. It is still unknown whether the endothelial function is
affected as an manifestation of the atherosclerotic process, changes in the driving
mechanical forces as WSS downstream of the valve, or other factors beyond physical pressure
effects.
The investigators hypothesized that altered haemodynamics may at least partly be responsible
for observed endothelial dysfunction in patients with AVS. Therefore, the aim of this study
is to investigate whether the resolution of AVS by transaortic valve implacement (TAVI)
affects WSS, improves endothelial dysfunction and decreases levels of circulating EMPs as
markers of endothelial integrity.
n/a
Observational Model: Cohort, Time Perspective: Prospective