Vitamin D Supplementation During Lactation

Deficiency, Vitamin D Clinical Trial

Official title: Randomized Control Trial of Vitamin D Supplementation During Lactation on Vitamin D in Maternal Milk

Status Completed

Clinical Trial Summary

This randomized, placebo-controlled trial in Thai pregnancy is conducted. The study aims to determine whether vitamin D3 1,800 IU/d supplementation in lactating mother improves vitamin D status of breastfed infant.

Clinical Trial Description

Vitamin D deficiency in pregnancy increases risk of gestational diabetes mellitus, pre-eclampsia, preterm birth, low birth weight and cesarean section. To against these adverse events, vitamin D supplementation in pregnancy and lactation is recommended, but dose ranges are varied. Then, this study is carried out in lactating mothers and their breastfed infants with maternal 25 Hydroxy-vitamin D (25OHD) levels of 10-30 ng/ml in third trimester. Subjects are divided into 2 groups, one is randomly assigned to 1,800 IU/d compared with maternal and infant controls receiving placebo. Maternal serum 25OHD and milk VitD will be measured by LC-MS/MS during lactation, and on cord blood at 6 weeks breastfed infants. This study is submitted for ethical consideration by relevant Ethics committee. ;

Related Conditions & MeSH terms

• Avitaminosis
• Deficiency, Vitamin D
• Vitamin D Deficiency

• NCT number: NCT02297568
• Study type: Interventional
• Source: Rajavithi Hospital
• Status: Completed
• Phase: N/A
• Start date: March 2014
• Completion date: June 2015