Healthy Clinical Trial
Official title:
The Effects of Dietary Carbohydrate and Fat on Hormone Regulators of Body Composition and Reproduction
This study will try to determine if intake of dietary fats or carbohydrates influences the
tendency to gain weight or accumulate body fat. It will examine how the hormones that
regulate weight may change with a shift from a balanced diet to one that is low in fat or
carbohydrate, irrespective of caloric intake.
Men and women between the ages of 18 and 40 years with a body mass index of 30 to 49 kg/m2
may be eligible for this study. Candidates will be screened with a history, physical
examination, blood tests and questionnaires regarding activity, prior diets, and eating
patterns.
Participants will follow two separate diet regimens for 5 days each. The first will be a
balanced diet, and the second will be either a low-fat/high-carbohydrate diet or a
low-carbohydrate/high-fat diet. The diets are not designed to produce weight loss.
Participants will receive all their meals and snacks for the two diets from the National
Institutes of Health and, for the first 3 days of each diet, will be seen as outpatients.
For days 4 and 5 of each diet, they will be admitted to the Clinical Center and will undergo
the following procedures:
- Blood tests - Blood samples will be collected every 30 minutes over a 24-hour period
through an indwelling catheter in the arm. A total of about 15 tablespoons will be
drawn for each of the two diets.
- 24-hour urine collection - One 24 hour urine collection will be done at home the day
before admission to the Clinical Center, and the other will be done during the hospital
stay.
- Urinalysis and pregnancy test - A small urine sample will be taken and women will
provide an additional sample for a pregnancy test.
- Body measurements - Height and weight will be measured using scales. Body fat will be
measured by two methods: skin fold thickness, measured with calipers in 5 separate
places; and body circumference measurements, in which body parts are measured with a
tape measure.
- Bod pod measurement - Proportions of fat and non-fat tissue in body weight are measured
while the participant sits in a capsule-like device for 5 minutes.
- Bioelectric impedance analysis - Proportions of body fat are measured based on
conduction of a small electric current.
- Total body water estimate -The proportion of body weight that is water is determined,
using a method that involves drinking a cup of a special kind of "heavy" water
(deuterium) and then measuring the amount of heavy water in a urine sample taken after
4 hours.
- Exercise - Participants will maintain their usual exercise routine, as it was before
beginning the study.
Caloric restriction triggers a number of homeostatic endocrine responses including suppression of leptin, gonadotropins, sex steroids, thyroid hormones, insulin and insulin like growth factors (IGFs) and elevation of growth hormone (GH) and cortisol. Some of these effects may be disadvantageous in terms of achieving loss of adipose tissue. There is little information on the role of specific macronutrients in the regulation of these important endocrine responses to food restriction. The present study aims to determine if dietary carbohydrate and/or lipid composition has significant effects on these hormonal regulators of body composition and metabolism, independent of total calorie supply. This will be achieved by comparing the short-term effects of isocaloric, weight maintenance diets restricted in either fat or carbohydrate with a standard balanced diet. Protein contribution as well as calorie content will be held constant in the 3 diets. Study subjects will be obese women and men (BMI 30-34.9 kg/m2) aged 18-40 years. Major study outcome parameters include: leptin, gonadotropin, GH and cortisol secretory dynamics; sex steroid, IGF, fasting insulin and glucose levels. ;
N/A
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06052553 -
A Study of TopSpin360 Training Device
|
N/A | |
Completed |
NCT05511077 -
Biomarkers of Oat Product Intake: The BiOAT Marker Study
|
N/A | |
Recruiting |
NCT04632485 -
Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
|
||
Completed |
NCT05931237 -
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
|
N/A | |
Terminated |
NCT04556032 -
Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women
|
N/A | |
Completed |
NCT04527718 -
Study of the Safety, Tolerability and Pharmacokinetics of 611 in Adult Healthy Volunteers
|
Phase 1 | |
Completed |
NCT04107441 -
AX-8 Drug Safety, Tolerability and Plasma Levels in Healthy Subjects
|
Phase 1 | |
Completed |
NCT04998695 -
Health Effects of Consuming Olive Pomace Oil
|
N/A | |
Completed |
NCT04065295 -
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 1356225
|
Phase 1 | |
Completed |
NCT01442831 -
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
|
Phase 1 | |
Terminated |
NCT05934942 -
A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood
|
Phase 1 | |
Recruiting |
NCT05525845 -
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
|
N/A | |
Completed |
NCT05515328 -
A Study in Healthy Men to Test How BI 685509 is Processed in the Body
|
Phase 1 | |
Completed |
NCT04967157 -
Cognitive Effects of Citicoline on Attention in Healthy Men and Women
|
N/A | |
Completed |
NCT05030857 -
Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects
|
Phase 1 | |
Recruiting |
NCT04494269 -
A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls
|
Phase 1 | |
Recruiting |
NCT04714294 -
Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers
|
Phase 1 | |
Completed |
NCT04539756 -
Writing Activities and Emotions
|
N/A | |
Recruiting |
NCT04098510 -
Concentration of MitoQ in Human Skeletal Muscle
|
N/A | |
Completed |
NCT03308110 -
Bioavailability and Food Effect Study of Two Formulations of PF-06650833
|
Phase 1 |