Deep Vein Thrombosis Clinical Trial
Official title:
Study of Elastographic Properties of the Clot by Technical SWIRE (Shear Wave Induced Resonance Elastography)
Deep vein thrombosis (DVT) is a vascular disease characterized by the formation of a thrombus
within the venous system, mainly the lower limbs. The clot structure directly influences both
its location, but also its progressive profile expansion material or regression and embolic
migration.
Few data are available regarding the evolution of structural properties of thrombus after an
acute episode of DVT. Thrombus formation is due to the polymerization of fibrinogen into
fibrin. Fibrin is a viscoelastic polymer. Its mechanical properties directly determine how
the thrombus responds to forces which it is subjected.
Determining the mechanical properties of the thrombus in vivo and ex vivo is expected to
study its evolutionary properties.
The main objective of the study is to characterize the in vivo properties of elastographic
thrombus in patients with proximal deep vein thrombosis (DVT), for quantitative elastography
performed at D0, D7, D30.
The ability to analyze the structural properties of the thrombus should allow us to then
correlate these properties to the evolving nature of the thrombus (embolic migration or not,
recanalization or not), and the effect of different treatment on the evolution of the
thrombus
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