Deep Partial Thickness Burn Clinical Trial
Official title:
The Clinical Efficacy of Epidermal Growth Factor With Silver Sulfadiazine Cream Compared With Silver Zinc Sulfadiazine Cream on Acceleration of Partial Thickness Burn Wound Healing
Partial thickness burn wounds are most likely to heal within 2-3 weeks mainly by mechanism
of epithelialization. However, it depends on the depth of the wounds and patient condition.
Infection is one of the most common complications causing delay in wound healing which might
affect to quality of patient's life. Generally, the standard treatment of partial thickness
burn wound is topical 1% silver sulfadiazine cream. Previous studies had been reported the
broad spectrum antimicrobial activity of silver sulfadiazine cream but it did not
demonstrate the accelerating effect of wound healing. Therefore, the combination of
substance which can promote wound healing to topical silver sulfadiazine cream might benefit
for partial thickness burn wound treatment.
The objective of this study was to compare the results of partial thickness burn wound
treatment at burn unit, Siriraj hospital with topical cream containing 1% silver
sulfadiazine plus 6% epidermal growth factor (EGF) and 1% silver zinc sulfadiazine. The
demographic data (age, sex, %body surface area burn), time of wound closure, pain and
itching, dose and type of pain and itching medication, adverse effect of topical medication,
some laboratory results and cost of expenses.
This is the prospective, double blinded, randomize-controlled study. The sample sizes were
partial thickness burn wound patients who were treated at burn unit, Siriraj hospital.
Patients were allocated into 2 groups receiving treatment with either topical silver
sulfadiazine plus EGF or silver zinc sulfadiazine. All parameter data were analyzed with
repeated measure ANOVA and independent t-test.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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