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Decompression Sickness clinical trials

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NCT ID: NCT06370897 Not yet recruiting - Clinical trials for Decompression Sickness

Prediction & Mechanisms of Recovery Following IEDS

Start date: June 2024
Phase:
Study type: Observational

Inner Ear Decompression sickness (IEDS) accounts for 20% of all types of decompression sickness (the bends) in divers. The condition commonly affects the peripheral vestibular system (inner ear). IEDS results in acute symptoms of dizzyness (vertigo) and imbalance. Even with the recommended treatment of hyperbaric oxygen therapy some people do not recovery fully. However, even in the presence of a permanent vestibular deficit many people can show a behavioural recovery where symptoms improve over time. Recovery can be aided by vestibular rehabilitation (VR) which is now routine for acute IEDS but was not provided before 2021, and is not widespread across the UK (United Kingdom) or world, meaning people may have a suboptimal recovery. This project will investigate if and how people recover after an acute episode of IEDS and whether people who had IEDS in the past show changes in the central (brain) processing of vestibular function and in symptoms of dizziness, balance and posture. This project has two main parts. Part one is a prospective observational study where people with an acute onset of IEDS are serially monitored while they are receiving hyperbaric treatment and VR over 10-14 days. Part two is a retrospective observational study where who have had IEDS in the past 15 years are re-assessed in a one-off session. The tests in both parts involve clinical tests and specialist eye movement recordings that assess vestibular function. We will also determine the site of any vestibular pathology by using selective stimulation of the vestibular end organ or nerve and assess whether there are any changes in how the structure and function of central vestibular pathways in the brain. In people with chronic IEDS with vestibular symptoms we will offer participants a course of VR over 12 weeks and assess whether this is associated with any improvement in symptoms.

NCT ID: NCT06216366 Not yet recruiting - Clinical trials for Decompression Sickness

Rhu-pGSN to Mitigate Proinflammatory Responses to Decompression in Healthy SCUBA Divers

Start date: June 1, 2024
Phase: Phase 2
Study type: Interventional

Healthy trained SCUBA divers will be randomized into three groups and exposed to a high-pressure profile in a hyperbaric chamber. The high-pressure profile simulates the pressure at a depth of 30 meters of sea water (MSW) for 35 minutes. In the control group, the subjects will receive intravenous normal saline immediately before and after the high-pressure exposure. The second group will receive intravenous recombinant human gelsolin (rhu-pGSN) 24 mg/kg immediately prior to the exposure, and saline post-exposure. The third group will receive saline pre-exposure and rhu-pGSN post-exposure. Blood samples will be collected at multiple time points pre- and post-exposure to assess levels of inflammatory markers, including interleukin (IL)-1β. Other assessments include screening for gas bubbles, a validated questionnaire to assess the incidence of clinical decompression sickness (DCS), measurement of plasma gelsolin (pGSN) levels, and measurement of anti-pGSN antibodies.

NCT ID: NCT04895501 Completed - Runners Clinical Trials

Effects of Shoe Longitudinal Bending Stiffness

FAT-FLEX
Start date: February 7, 2022
Phase: N/A
Study type: Interventional

Carbon plates inserted in competitive running shoes have been increasingly used in the past 2-3 years and several investigations have shown that these plates increase the longitudinal bending stiffness (LBS) of the shoe. It leads to a redistribution of muscle work and to a modification of the force generation conditions, which may reduce the energy cost of running (Cr) and improve performance.

NCT ID: NCT04791488 Recruiting - Clinical trials for Decompression Sickness

Impact of Hyperoxia and Involvement of the Immune System in Diving Accident

OXYDIVE
Start date: March 30, 2022
Phase: N/A
Study type: Interventional

The impact of oxygen therapy in many pathologies has been subject of recent work, arguing both favourable and harmful effects. Consequently, one can wonder about the influence of hyperoxic gas mixture during diving on the genesis of decompression sickness, but also about the systematic application of normobaric and hyperbaric oxygen in case of proven decompression sickness. In mammals, normoxic concentrations have been redefined at 20-100 mbars at the extracellular level and below 10 mbars in the mitochondria. Under hyperbaric conditions, most of the oxygen being dissolved in blood plasma, a state of hyperoxia is established which escapes the usual delivery and regulation system represented by red blood cells. The results of our team's previous work suggest a specific effect of diving on the levels of circulating mitochondrial DNA (mtDNA), suggesting cellular destruction linked to hyperoxia/hyperbaria. In fact, our studies, carried out on both animals and human divers, have shown that diving accident leads to an increase in mtDNA levels and an immune reaction through the mobilisation of leukocytes. The main objective of this study is to compare the influence of oxygen partial pressure levels on the evolution of clinical and biological variables during hyperbaric oxygen therapy sessions in healthy versus injured divers.

NCT ID: NCT04459481 Completed - Clinical trials for Intubation;Difficult

Comparison of Two Bending Angles for Nasotracheal Intubation With a Malleable Vedio Stylet

Start date: June 4, 2020
Phase: N/A
Study type: Interventional

Video intubating stylet can be safely and effectively used for nasotracheal intubation, but the optimal bending angle is still unknown. In this study, the optimal bending angle will be determined by comparing the intubation time and success rate of nasotracheal intubation with video intubating stylet at two different bending angles.

NCT ID: NCT03693235 Completed - Tracheal Intubation Clinical Trials

Adequate Bending Angle of a Lightwand

Start date: November 14, 2018
Phase: N/A
Study type: Interventional

For tracheal intubation with a lightwand, adequate bending angle was not exactly investigated. The purpose of the study is compare three bending angles of lightwands for safe and efficient tracheal intubation.

NCT ID: NCT03390335 Completed - Clinical trials for Acute Mountain Sickness

Decompression Tables for Diving at Altitude

Start date: February 13, 2018
Phase: N/A
Study type: Interventional

The aims of this proposal are to test current USN procedures for adjusting decompression procedures during air diving at 8,000 and 10,000 ft altitude and to provide a decompression algorithm for no-stop dives to 100 feet of sea water (fsw) at 10,000 and 12,000 ft altitude using enriched O2 (PO2=1.3 ATM). Additionally, the experiments will determine whether a period of hyperbaric hyperoxia, such as would be experienced during a dive at altitude, reverses altitude acclimatization, resulting in a return of acute mountain sickness (AMS) symptoms.

NCT ID: NCT03192956 Recruiting - Clinical trials for Decompression Sickness

Markers of Central Nervous System Injury in Decompression Sickness

DCS NEURO
Start date: May 1, 2017
Phase:
Study type: Observational

Research hypothesis - There is a correlation between the quantity of fluid markers of CNS injury in blood and DCS. - There is a correlation between quantity and kind of fluid markers of CNS injury in blood and both diving profile and severity of DCS. - There is a correlation between the quantity of inflammatory markers in blood an DCS. Objectives: - Assess whether individuals suffering decompression sickness exhibit fluid markers of central nervous system injury. - Evaluate the correlation between quantity and kind of fluid marker of CNS injury and clinical signs of neurological impairment. - Evaluate the correlation between quantity and kind of fluid marker of CNS injury and clinical outcome after 3-6 months. - Assess whether individuals suffering decompression sickness exhibit inflammatory markers in blood.

NCT ID: NCT02736006 Completed - Clinical trials for Decompression Sickness

Decreases in Diffusing Lung Capacity for Carbon Monoxide (DLCO) in Occupational Divers and Their Impact on Decompression Sickness Risks

DACODEC
Start date: March 22, 2016
Phase: N/A
Study type: Interventional

Diving disorders and particularly Decompression sickness (DCS) represent a major concern in recreational and occupational pressure-related activities. As a result of decompression from higher to lower ambient pressure bubbles which are formed in vascular flow and in tissues take part in embolism then resulting in DCS. Individual factors such as vascular or respiratory defects are now considered to increase the risk of this dysbarism disease.

NCT ID: NCT02483650 Enrolling by invitation - Clinical trials for Carbon Monoxide Poisoning

Hyperbaric Oxygen Therapy Registry

HBOTR
Start date: January 2005
Phase:
Study type: Observational [Patient Registry]

The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of "Stage 2 of Meaningful Use," including data provided to meet PQRS requirements via the registry's QCDR mission. Goals include understanding the value of HBOT among patients treated for a variety of conditions in relation to the frequency and severity of HBOT side effects. While randomized, controlled trials can establish the efficacy of treatments like HBOT, because they routinely exclude patients with co-morbid conditions common to those patients seen in usual clinical practice, the results of RCTs are usually non-generalizable. Real world data can be used to better understand the effectiveness of HBOT among typical patients, as well as the risks associated with treatment.