Decompensated Heart Failure Clinical Trial
Official title:
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure
This study is designed to investigate the quantitative effects of sodium-free chloride supplementation on electrolyte balance, volume status, and sodium avidity in stable heart failure patients in a highly controlled environment.
The overarching goal of this study is to develop a comprehensive understanding of the biology and therapeutic potential of sodium-free chloride supplementation. While sodium homeostasis has been the focus of substantial investigation, very little research has been devoted to understanding chloride homeostasis. Thus, this proposal is designed to obtain the full spectrum of information pertaining to chloride, such as novel areas with great interest by the scientific community (i.e. modulation of the WNK-kinase system and the use of exosomes), to more practical/basic questions (i.e. what happens to sodium chloride balance when a patient is challenged with chloride). This study is designed as a highly controlled inpatient "GCRC" arm to be compared to a real world efficacy study that has been proposed as a separate study. With extensive biobanking and analysis of samples in the inpatient setting, we will be able to deliver a great wealth of information on the biology and therapeutic potential of manipulating chloride homeostasis in heart failure. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05910437 -
Optimizing Treatments for Heart Failure During Hospitalization
|
||
| Terminated |
NCT00355017 -
BNP Guided Care in Addition to Multidisciplinary Care
|
N/A | |
| Active, not recruiting |
NCT03701880 -
Early Use of Ivabradine in Heart Failure
|
N/A | |
| Recruiting |
NCT03157219 -
Manipal Heart Failure Registry (MHFR)
|
N/A | |
| Recruiting |
NCT06114498 -
Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction
|
||
| Completed |
NCT03838003 -
Exercise in Patients Admitted With Recently Decompensated Heart Failure
|
N/A | |
| Recruiting |
NCT02997462 -
Monocyte Phenotypic Changes in Heart Failure
|
||
| Completed |
NCT04493346 -
Shear Wave Elastography
|
||
| Recruiting |
NCT02666651 -
Regional Tolvaptan Registry
|
Phase 4 | |
| Recruiting |
NCT02236247 -
Control of Sinus Node Tachycardia as an Additional Therapy in Patients With Decompensated Heart Failure
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06273397 -
Acetazolamide or Metolazone in Acute Heart Failure
|
N/A | |
| Recruiting |
NCT06286423 -
Colchicine in Acutely Decompensated HFREF
|
Phase 4 | |
| Completed |
NCT05927285 -
Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1
|
N/A | |
| Withdrawn |
NCT04572867 -
Aquapheresis Efficacy in Outpatients With Decompensated Heart Failure
|
N/A | |
| Completed |
NCT02157506 -
A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure
|
Phase 2 | |
| Recruiting |
NCT03914222 -
Comparing PA Compliance During and After Decompensation in HFP
|
N/A | |
| Recruiting |
NCT03009552 -
Speckle Tracking Echocardiography Adds Information in Decompensated Heart Failure
|
N/A | |
| Completed |
NCT04019314 -
Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI)
|
N/A | |
| Recruiting |
NCT02649517 -
Clinical and Morphological Characteristics of Chronic Inflammation in the Myocardium in Patients With Decompensated HF With Ischemic Systolic Dysfunction
|
N/A | |
| Recruiting |
NCT05090930 -
Innovative Technologies for the Treatment of Pulmonary and Heart Failure
|
N/A |