Death Clinical Trial
Official title:
An "Old" Biomarker That Can Learn New Tricks: Prognostic Role of Free Psa Ratio at Biochemical Recurrence After Radical Treatments for Prostate Cancer
Measurement of Free PSA ratio in patients after definitive radical treatment for prostate cancer, and assessment of whether post-treatment free PSA ratio can function as a biomarker for advanced disease in prostate cancer patients.
Prostatic specific antigen (PSA) circulates mostly in complex with protease inhibitors, but
10-30% circulates as inactive free-PSA (FPSA). In patients with prostate cancer (PCa),
pretreatment FPSA is lower and used to risk-stratify patients for biopsy. However,
posttreatment FPSA ratio (FPSAR) is rarely quantified, with an unexplored clinical value.
Methods The institutional database was queried to identify patients following radical
prostatectomy (RP cohort) or radiotherapy (RT cohort) between 2000 and 2017. For validation,
the investigators identified an independent prospective cohort with biochemical recurrence
(BCR) after RP, using biobank samples (biobank cohort). All patients had at least one
posttreatment FPSAR test. Kaplan-Meier (KM) method was used to compare the metastasis-free
(MFS), castration-resistant PCa (CRPC)-free, and cancer-specific-survival (CSS) rates.
Multivariable Cox models determined the association between posttreatment FPSAR, metastases,
and CRPC.
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