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Deafness clinical trials

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NCT ID: NCT05970211 Recruiting - Hearing Loss Clinical Trials

Early Age-Related Hearing Loss Investigation Pilot Study

P-EARLHI
Start date: June 19, 2023
Phase: N/A
Study type: Interventional

The purpose of this clinical trial pilot is to obtain feasibility and pilot data necessary to inform the hearing intervention being designed for a larger R01 clinical trial that seeks to determine whether best practice hearing aid intervention impacts hearing-related outcomes in adults with hearing loss aged 55 to 75 years. Secondary purposes include: To determine what effects best practice hearing aid intervention has on physical, social, and quality of life outcomes in adults with hearing loss aged 55 to 75 years.

NCT ID: NCT05964725 Recruiting - Clinical trials for Transcranial Direct Current Stimulation

The Study on Effect and Neural Network Mechanism of Transcranial Direct Current Stimulation for Sudden Deafness With Tinnitus

Start date: November 23, 2023
Phase: N/A
Study type: Interventional

This clinical study is prospective, single-center, randomized, controlled, double-blind clinical trail, which entitled transcranial electrical stimulation for the treatment of acute tinnitus approved by Sun Yat-sen University, and intends to recruit 86 patients with sudden deafness and tinnitus. For acute subjective tinnitus, a common otological disease, the study gave the experimental group patients received tDCS with electrodes positioned over the left temporal cortex for 5 days. To assess the efficacy of conventional medical therapy and tDCS by comparing changes in anterior and posterior tinnitus-related subjective scale scores, such as THI, VAS, BAI, BDI, PSQI, and hearing recovery, in patients who received tDCS, to determine whether tDCS is effective in improving acute tinnitus, and whether it is superior to conventional tinnitus treatment. In addition, the study will continue to follow patients for 1 month,3 months, and 6 months after the end of treatment to observe the long-term sustained efficacy of tDCS. This clinical trail will also evaluate tDCS from the perspective of compliance and safety, and explore the factors affecting the efficacy of this therapy.

NCT ID: NCT05962359 Recruiting - Clinical trials for Social Communication

Neural Prediction to Enhance Language

Start date: January 23, 2023
Phase: N/A
Study type: Interventional

The language outcome of children receiving cochlear implantation to address bilateral sensorineural hearing loss is more variable than that of typical hearing children. The research is focused upon development of neural predictive models based upon brain imaging to forecast language after cochlear implantation on the individual child level. The long-term goal is improving children's language by using predictive models to enable a custom "predict to prescribe" approach to intervene with more effective behavioral therapy for children at risk to develop poorer language. The investigators previously developed models for short term language outcome of English-learning implanted children. The aims of this study are to 1. Develop models able to predict long term outcome for English- learning and Spanish-learning children; and 2. To evaluate whether English-learning children predicted to achieve lower language based on the investigators' previously constructed models can demonstrate significant gains from Parent Implemented Communication Treatment (PICT). PICT is an intensive parent education program about strategies to improve children's communication.

NCT ID: NCT05955469 Recruiting - Clinical trials for Sensorineural Hearing Loss, Bilateral

Comparison in New Cochlear Implanted Subjects of a Tonotopy-based Bimodal Fitting and a Conventional Fitting

Start date: October 15, 2023
Phase: N/A
Study type: Interventional

Main objective: For a bimodal fitting (hearing aid (HA) + cochlear implant (CI)): Comparison of a tonotopy based fitting strategy (TFS4) to a default fitting strategy (FS4) for the speech recognition in noise. Secondary objectives: Comparison of TFS4 to FS4 for speech recognition in quiet. Comparison of TFS4 to FS4 for the auditory skills experienced by the subject.

NCT ID: NCT05946057 Recruiting - Hearing Impairment Clinical Trials

Otoferlin Patient Registry and Natural History Study

Start date: February 21, 2023
Phase:
Study type: Observational [Patient Registry]

This registry is designed to collect comprehensive information about the molecular genetic diagnoses of individuals with otoferlin-associated hearing impairment and clinical information to support a natural history study.

NCT ID: NCT05943509 Recruiting - Deafness Clinical Trials

Hearing Program in Primary Care

Start date: February 15, 2024
Phase: N/A
Study type: Interventional

During a primary care visit, investigators will screen and identify participants with hearing loss and then randomize to a) counseling on accessible assistive listening devices or b) referral to traditional audiology care pathway alone.

NCT ID: NCT05942261 Recruiting - Clinical trials for Deafness Neurosensory

Rehabilitation Methods of Children With Cochlear Implant

MRSI
Start date: May 9, 2023
Phase:
Study type: Observational

The cochlear implant represents the gold standard in the treatment of children with bilateral severe-profound deafness. However, the current Italian and international guidelines do not address the issue of rehabilitation and how the different rehabilitation methods should be applied in relation to the different clinical pictures. The aim of this study is therefore to describe which methods are used today in the rehabilitation of deaf children with cochlear implants followed at the Phoniatrics and Speech Therapy service of the A. Gemelli Polyclinic Foundation. The creation of a questionnaire directed to the speech therapist who treats the specific patient is available in order to collect data concerning the characteristics of the setting and the rehabilitation method in relation to the most applied methodologies, i.e. Auditory-verbal therapy, oral-cognitive therapy, bimodal method and the Drežančić method.

NCT ID: NCT05902351 Recruiting - Clinical trials for Charcot-Marie-Tooth Disease

Natural History Study for Charcot Marie Tooth Disease

Start date: November 1, 2013
Phase:
Study type: Observational

The goal of this Natural History Study for Charcot-Marie-Tooth is to acquire, record, and analyze patient-reported data and associated genetic reports, Electronic Health Records (EHRs) and clinical notes to identify the burden, diagnostic journey, and prevalence of disease that will aid scientists in their work toward finding a cure. Participants will be asked to complete a Natural History Survey.

NCT ID: NCT05867173 Recruiting - Deafness Clinical Trials

Perceptual Consequences of Cochlear Implant Electrode-neuron Interfaces

Start date: September 16, 2022
Phase: N/A
Study type: Interventional

Despite the success of cochlear implants, devices surgically placed in the inner ears of patients with severe hearing loss, there remains substantial variability in the overall speech perception outcomes for the children and adults who receive them. The main goals of this project are: i) to improve our understanding of how cochlear implants affect the developing auditory system, ii) apply that knowledge to test new methods for programming children and adults, and iii) to study how long it takes listeners to adapt to new cochlear implant programs over the short- and long-term. The results will improve our understanding of how the deafened auditory system develops with cochlear implant stimulation and advance clinical practice to improve hearing outcomes in cochlear implant listeners.

NCT ID: NCT05854719 Recruiting - Hearing Impairment Clinical Trials

Eyes On Lips? Speechreading Skills and Facial Expression Discrimination in Children With and Without Impaired Hearing

Start date: May 12, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to find out the role of background factors and gaze use in children's speechreading performance. The main questions it aims to answer are: - Which background factors and eye gaze patterns are associated with the best speechreading results in hearing children and those with hearing impairment/loss? - Are children's gaze patterns and facial expression discrimination associated with interpretation of emotional contents of verbal messages in speechreading? - What is the efficacy of intervention that is based on the use of a speechreading application to be developed? Participants will be - tested with linguistic and cognitive tests and tasks - tested with a speechreading test and tasks with or without simultaneous eye-tracking - about half of the participants with hearing impairment/loss will train speechreading with an application Researchers will compare the different age groups and the results of hearing children to those of children with impaired hearing to see if there are differences.