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Deafness clinical trials

View clinical trials related to Deafness.

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NCT ID: NCT02132130 Completed - Clinical trials for Unilateral Severe to Profound Hearing Loss OR Bilateral Severe to Profound Hearing Loss

Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss

Start date: June 23, 2014
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of the study was to evaluate the safety, tolerability, and the potential ability of CGF166 delivered through IL-infusion to improve hearing. CGF166 is a recombinant adenovirus 5 (Ad5) vector containing a cDNA encoding the human Atonal transcription factor (Hath1).

NCT ID: NCT02122458 Completed - Hearing Impairment Clinical Trials

Blast Exposed Veterans With Auditory Complaints

Start date: August 1, 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to study blast-exposed Veterans who report hearing handicap but show normal or near normal results on standard audiometric testing. The characteristics and nature of their auditory and auditory-related skills will be examined, along with whether coexisting PTSD contributes to the hearing problems of these Veterans. In a preliminary treatment study, a sub-sample of these Veterans will be fitted with mild-gain hearing aids to determine if they benefit from low-level amplification of high-frequency sounds.

NCT ID: NCT02105441 Completed - Clinical trials for Severe Unilateral Sensorineural Hearing Loss

Cochlear Implantation Among Adults and Older Children With Unilateral or Asymmetric Hearing Loss

CI and SSD
Start date: March 2014
Phase:
Study type: Observational

Do adults and children over 7 years of age with unilateral or assymetric hearing loss benefit from cochlear implantation on the worst hearing side.

NCT ID: NCT02096809 Completed - Clinical trials for Hearing Loss - Conductive

Stability of the Cochlear Baha BI300/BA400 Implant System Loaded From 1 Week Post-surgery

Start date: March 2014
Phase: N/A
Study type: Interventional

Objectives - To evaluate the safety of processor loading of the Cochlear BI300/BA400 implant system 1 week after implantation - To evaluate the short term soft tissue healing and the long term skin reaction, with the new Cochlear BI300/BA400 implant system using the linear incision without subcutaneous tissue reduction. - To produce reference data regarding the stability of the BI300/BA400 implant system. Study design: Prospective cohort study. Patients: 24 adults with anticipated normal skin and bone quality eligible for bone anchored implant surgery. Intervention: Loading of the sound processor one week after surgery Main outcome measures: Implant stability, soft tissue reaction, skin overgrowth, pain and numbness will be assessed. It is hypothesized that implant loading can be performed one week after surgery without any changes in implant stability, soft tissue reaction, skin overgrowth, pain or numbness around implant.

NCT ID: NCT02094625 Completed - Osteosarcoma Clinical Trials

NAC to Prevent Cisplatin-induced Hearing Loss

Start date: March 2016
Phase: Phase 1
Study type: Interventional

Cisplatin is a key chemotherapy agent for the treatment of multiple childhood cancers but causes permanent hearing loss. This study investigates the drug N-acetylcysteine (NAC) to determine the dose necessary to protect hearing and also how well tolerated NAC is when combined with chemotherapy.

NCT ID: NCT02092337 Completed - Hearing Impairment Clinical Trials

Computer-Assisted Speech Training for Hearing Aid Users

Start date: June 2007
Phase: N/A
Study type: Interventional

Computer-assisted speech training is a speech recognition training system developed for cochlear implant users. With minimal facilities and skills, cochlear implant users can conduct this training at home. The purpose of this study was to apply this system to adolescent and young adult hearing aid users with prelingual severe to profound hearing loss.

NCT ID: NCT02082431 Completed - Clinical trials for Sensorineural Hearing Loss

Determine the Incidence of Long QT Amongst a Large Cohort of Subjects Diagnosed With Unilateral or Bilateral Sensorineural Hearing Loss.

Start date: August 2014
Phase:
Study type: Observational

The purpose of this study is to determine the true incidence of long QT (LQT) amongst a large cohort of subjects diagnosed with unilateral (right/left) or bilateral sensorineural hearing loss.

NCT ID: NCT02075229 Completed - Clinical trials for Bilateral Sensorineural Hearing Loss

Evaluation of Revised Indicatons (ERID) for Cochlear Implant Candidacy for the Adult CMS Population

Start date: February 2014
Phase:
Study type: Observational

Purpose: The purpose of this study is 1) to evaluate the safety and efficacy of currently available multichannel cochlear implant systems for newly implanted adults with an indication based on open-set sentence recognition that expand criteria currently used by Center for Medicare & Medicaid Services (CMS), and 2) to assess the correlation between measures of speech recognition in candidates for cochlear implants and their utility in predicting audiologic and quality of life outcomes after implantation. Participants: Adults (≥ 65 years of age) and CMS-eligible as a primary source of medical insurance coverage. Procedures (methods): Evaluate objective and subjective outcomes of cochlear implantation in a patient population that does not meet current CMS candidacy criteria.

NCT ID: NCT02064478 Completed - Clinical trials for Conductive Hearing Loss

Clinical Survey of Oticon Medical Ponto Implants and a Surgical Technique With Tissue Preservation

Start date: February 2014
Phase: N/A
Study type: Observational

A bone anchored hearing system is used to improve hearing for patients with e.g. conductive/mixed hearing loss or single sided deafness. With this type of system, a titanium implant is installed in the temporal bone, where it osseointegrates, i.e. integrates with the bone. An abutment (also in titanium) is attached to the implants and penetrates the skin. The sound processor (hearing aid) is then connected to the abutment, and can be attached and removed by the patient via a snap-coupling. This type of system has been successfully implanted in more than 100.000 patients. Recently, a simplified surgical procedure, where no skin thinning around the abutment is made, was approved. The results after using this installation technique, here called soft tissue preservation, are the focus of this study. The objective of the study is to compare the outcomes after a surgical procedure with soft tissue preservation (test) and a surgery with soft tissue reduction (control) for placing Oticon Medical Ponto implants and abutments. The main hypothesis is that patient numbness around the implant is less in the test group compared to the control group.

NCT ID: NCT02045511 Completed - Clinical trials for Personal Communication

The Baltimore HEARS Pilot Study

HEARS
Start date: February 2014
Phase: N/A
Study type: Interventional

The primary purpose of the study is to develop and test the preliminary efficacy of a first-in-kind community-based intervention to provide affordable, accessible and effective hearing health care to low-income, minority older adults.