Cytomegalovirus Infections Clinical Trial
Official title:
A Multicenter Prospective Observational Study to Evaluate Cytomegalovirus (CMV)-Specific Response Measured by QuantiFeron® and Overall Immunologic Response Measured by ImmuKnow® in Lung Transplant Patients With CMV-positive Serology (R+) Prior to Transplant and Its Involvement in the Development of CMV Infection
The purpose of this study is to determine the sensitivity and specificity of QuantiFeron® and ImmuKnow® in combination for early detection of patients who will develop CMV infection in lung transplant patients with CMV-positive serology (R+) prior to transplant.
The secondary objectives of the study are:
- To evaluate Cytomegalovirus (CMV)-specific immune response measured by QuantiFeron®.
- To evaluate overall immune response measured by ImmuKnow®.
- To study the course of QuantiFeron® and ImmuKnow®over the follow-up period.
- To correlate levels of ImmuKnow® and QuantiFeron®.
- To evaluate the relationship between levels and doses of immunosuppressants and their
relationship to degree of overall immunosuppression (ImmuKnow®).
- To evaluate the relationship between infections, immunological complications and degree
of overall immunosuppression (ImmuKnow®).
;
Observational Model: Case-Only, Time Perspective: Prospective
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