Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys

Cytokines Clinical Trial

Official title:

Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05022992
• Other study ID #: 2020-03179
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 2021
• Est. completion date: March 2022

Study information

• Verified date: August 2021
• Source: Umeå University
• Contact: Apostolos Theos, PhD
• Phone: +46702811565
• Email: apostolos.theos[@]umu.se
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

: Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.

Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.

Description:

Preliminary measurements:

Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.

Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: March 2022
• Est. primary completion date: December 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 9 Years to 17 Years

Eligibility

Inclusion Criteria:

• Healthy boys (n=40)

• Physically active, defined as a minimum of 2 years experience in a sports club

• Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys

• No previous experience of structured resistance training

Exclusion Criteria:

• Chronic diseases that affect full participation

• Injuries that limit full participation

Related Conditions & MeSH terms

• Cytokines
• Hormones

Intervention

Other:
• Resistance Training
Both groups will perform a resistance training session consisted of 10 reps x 3 set of upper- and lower-body resistance exercises.

Locations

Country	Name	City	State
Sweden	Umeå Movement and Exercise Laboratory, Umeå University	Umeå	Västerbotten

Sponsors (1)

Lead Sponsor	Collaborator
Umeå University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Growth Hormone Baseline	Blood Concentration of Growth Hormone	Baseline testing before the exercise intervention (Pre values)
Primary	Change from Baseline Growth Hormone Post exercise	Blood Concentration of Growth Hormone	Right after the completion of the exercise intervention (Post values)
Primary	Change from Baseline Growth Hormone 15 minutes post exercise	Blood Concentration of Growth Hormone	15 minutes after the completion of the exercise intervention (Post-15 values)
Primary	Change from Baseline Growth Hormone 30 minutes post exercise	Blood Concentration of Growth Hormone	30 minutes after the completion of the exercise intervention (Post-30 values)
Primary	Insulin-like Growth Factor-1 Baseline	Blood concentration of Insulin-like Growth Factor-1	Baseline testing before the exercise intervention (Pre values)
Primary	Change from Baseline Insulin-like Growth Factor-1 Post exercise	Blood concentration of Insulin-like Growth Factor-1	Right after the completion of the exercise intervention (Post values)
Primary	Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise	Blood concentration of Insulin-like Growth Factor-1	15 minutes after the completion of the exercise intervention (Post-15 values)
Primary	Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise	Blood concentration of Insulin-like Growth Factor-1	30 minutes after the completion of the exercise intervention (Post-30 values)
Secondary	Cortisol Baseline	Blood concentration of Cortisol	Baseline testing before the exercise intervention (Pre values)
Secondary	Change from Baseline Cortisol Post exercise	Blood concentration of Cortisol	Right after the completion of the exercise intervention (Post values)
Secondary	Change from Baseline Cortisol 15 minutes Post exercise	Blood concentration of Cortisol	15 minutes after the completion of the exercise intervention (Post-15 values)
Secondary	Change from Baseline Cortisol 30 minutes Post exercise	Blood concentration of Cortisol	30 minutes after the completion of the exercise intervention (Post-30 values)
Secondary	Testosterone Baseline	Blood concentration of testosterone	Baseline testing before the exercise intervention (Pre values)
Secondary	Change from Baseline Testosterone Post Exercise	Blood concentration of testosterone	Right after the completion of the exercise intervention (Post values)
Secondary	Change from Baseline Testosterone 15 minutes Post Exercise	Blood concentration of testosterone	15 minutes after the completion of the exercise intervention (Post-15 values)
Secondary	Change from Baseline Testosterone 30 minutes Post Exercise	Blood concentration of testosterone	30 minutes after the completion of the exercise intervention (Post-30 values)
Secondary	Interleukin-6 Baseline	Blood concentration of Interleukin-6	Baseline testing before the exercise intervention (Pre values)
Secondary	Change from Baseline Interleukin-6 Post Exercise	Blood concentration of Interleukin-6	Right after the completion of the exercise intervention (Post values)
Secondary	Change from Baseline Interleukin-6 15 minutes Post Exercise	Blood concentration of Interleukin-6	15 minutes after the completion of the exercise intervention (Post-15 values)
Secondary	Change from Baseline Interleukin-6 30 minutes Post Exercise	Blood concentration of Interleukin-6	30 minutes after the completion of the exercise intervention (Post-30 values)
Secondary	Interleukin-1 alpha Baseline	Blood concentration of Interleukin-1 alpha	Baseline testing before the exercise intervention (Pre values)
Secondary	Change from Baseline Interleukin-1 alpha Post Exercise	Blood concentration of Interleukin-1 alpha	Right after the completion of the exercise intervention (Post values)
Secondary	Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise	Blood concentration of Interleukin-1 alpha	15 minutes after the completion of the exercise intervention (Post-15 values)
Secondary	Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise	Blood concentration of Interleukin-1 alpha	30 minutes after the completion of the exercise intervention (Post-30 values)
Secondary	Tumor Necrosis Factor alpha Baseline	Blood concentration of Tumor Necrosis Factor alpha	Baseline testing before the exercise intervention (Pre values)
Secondary	Change from Baseline Tumor Necrosis Factor alpha Post Exercise	Blood concentration of Tumor Necrosis Factor alpha	Right after the completion of the exercise intervention (Post values)
Secondary	Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise	Blood concentration of Tumor Necrosis Factor alpha	15 minutes after the completion of the exercise intervention (Post-15 values)
Secondary	Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise	Blood concentration of Tumor Necrosis Factor alpha	30 minutes after the completion of the exercise intervention (Post-30 values)
Secondary	Sex Hormone Binding Globulin Baseline	Blood concentration of Sex Hormone Binding Globulin	Baseline testing before the exercise intervention (Pre values)
Secondary	Change from Baseline Baseline Sex Hormone Binding Post Exercise	Blood concentration of Sex Hormone Binding Globulin	Right after the completion of the exercise intervention (Post values)
Secondary	Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise	Blood concentration of Sex Hormone Binding Globulin	15 minutes after the completion of the exercise intervention (Post-15 values)
Secondary	Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise	Blood concentration of Sex Hormone Binding Globulin	30 minutes after the completion of the exercise intervention (Post-30 values)