Citrate Versus Heparin in Continuous Renal Replacement Therapy :

Status Completed

Clinical Trial Summary

This study is a prospective, multicenter, open-label randomized trial comparing regional citrate anticoagulation (RCA) with heparin-free protocol. The function mode was continuous venovenous hemodiafiltration (CVVHDF) in post-dilution mode. The investigators measured hemodynamic changes at certain time points after starting CRRT (0, 6, 12, 24, 48, 72 hr).Levels of inflammatory cytokine (IL-1β, IL-6, IL-8, IL-10 and TNF-ɑ) were measured at day 1 and day 3

Clinical Trial Description

Twenty patients were randomized into heparin group and 11 patients were in citrate group. The cardiac performance were not significantly different between 2 groups at every time point. The inflammatory cytokines declined similarly in both treatment arms. The maximum filter survivial time was longer in a RCA group but not reach statistically significant (44.64±26.56 hr vs p=0.693 in citrate and heparin free group respectively).There was no serious side effects dung both treatment arm even in the group of liver dysfunction patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04865510
Study type	Interventional
Source	Bangkok Metropolitan Administration Medical College and Vajira Hospital
Contact
Status	Completed
Phase	N/A
Start date	February 4, 2019
Completion date	March 31, 2021

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