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Anti-IL6 and Corticosteroid Monotherapy vs Combination in COVID-19

Critical Illness Clinical Trial

Official title:
Clinical Outcome of Anti-IL6 and Corticosteroid Monotherapy vs Combination in COVID-19 Cytokine Release Syndrome

Clinical Trial Summary

The cytokine storms mediated by over production of proinflammatory cytokines have been observed in a large population of critically ill patients infected with COVID-19. Patients diagnosed with cytokine storms progress to cardiovascular collapse, multiple organ dysfunction and death rapidly. Therefore, early identification, treatment and prevention of the cytokine storms are of crucial importance for the patients. Immuomedulator such as interleukin-6 (IL-6) antagonist, emerged as an alternative treatment for COVID-19 patients with a risk of cytokine storms recently. In this study, we aimed to evaluate the safety and efficacy of anti-IL6 alone vs anti-IL6 corticosteroid combination in patients with COVID-19 pneumonia

Clinical Trial Description

This study will provide further insight whether anti-IL6 alone provide same efficacy and clinical outcome with reasonable side effects profile compared to anti-IL6 + corticosteroid and might serve as a corticosteroid sparing agents in COVID-19 patient with cytokine storms. Data elements will be retrieved from VIRUS registry which is a prospective, non-interventional, multi-center, multi-national observational cross sectional study ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04486521
Study type Observational
Source King Faisal Specialist Hospital & Research Center
Contact Marwa Amer, PharmD,BCPS, BCCCP
Phone +966114647272
Email mamer@kfshrc.edu.sa
Status Recruiting
Phase
Start date July 22, 2020
Completion date July 22, 2021
View Details
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