Pharmacokinetics of Omadacycline in Cystic Fibrosis

Status Completed

Clinical Trial Summary

The purpose of this study is to characterize the pharmacokinetics of intravenous and oral omadacycline in patients with cystic fibrosis.

Clinical Trial Description

Omadacycline exhibits excellent activity against bacteria including methicillin-resistant Staphylococcus aureus (MRSA), Burkholderia cepacia, and Nontuberculous mycobacteria (NTM) that are a potential source of lung infection in CF patients. As omadacycline demonstrates antimicrobial activity against a number of pathogens in CF, the investigators hope to learn the optimal dose of omadacycline necessary to treat lung infections in patients with CF in the future. The study hypothesis is that omadacycline will exhibit good oral bioavailability in patients with CF. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04460586
Study type	Interventional
Source	University of Southern California
Contact
Status	Completed
Phase	Phase 4
Start date	July 1, 2021
Completion date	December 31, 2023

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