Cystic Fibrosis Clinical Trial
Official title:
Comparative Analysis of Outcome Measures From Sit-to-stand Test Between Cystic Fibrosis and Healthy Subjects.
Introduction: In recent years, since the discovery of the cystic fibrosis (CF) transmembrane
conductance regulator gene in human skeletal muscle, there appears to be growing interest in
the measurement of muscle function in CF. One of the most used test in other chronic
pulmonary diseases is the Sit-to-Stand test (STS) which consists of simply getting up from a
chair. Although the main result of the STS test is the time developed during the task, the
velocity and power generated during the task are considered very important variables to
detect the functional decline. However, from our knowledge, no study has previously analyzed
the differences in time, velocity and muscle power developed during the STS test in patients
with CF and their respective healthy controls.
Objectives: To compare the values gained from handgrip strength, walking speed and STS test
(time, velocity, and muscle power) in a group of patients with CF and their respective
healthy controls, and to analyze if these differences (if any) are associated with lung
function in patients with CF.
Methods: Cross-sectional study with a sample of 60 participants (30 patients diagnosed with
CF and 30 healthy subjects) between 18-65 years old. The STS test will be measured through
slow-motion video recording with a smartphone device (240 images per second) which will
report the time, velocity and power generated during the test. Walking speed and handgrip
strength will be also measured. Additionally, the relationship between the variables obtained
during the test and the lung function of patients with CF will be analized.
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